ArticleThe Analyst2009
Selective detection of endogenous thiols using microchip-based flow analysis and mercury/gold amalgam microelectrodes.
Article in The Analyst, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed.
- 3D-Printed Microfluidic Device with In-line Amperometric Detection that Also Enables Multi-Modal Detection.Analytical methods : advancing methods and applications · 2020Article
- Ratiometric quantitation of thiol metabolites using non-isotopic mass tags.Analytica chimica acta · 2018Article
- Integrated hybrid polystyrene-polydimethylsiloxane device for monitoring cellular release with microchip electrophoresis and electrochemical detection.Analytical methods : advancing methods and applications · 2015Article
- Fabrication and Characterization of All-Polystyrene Microfluidic Devices with Integrated Electrodes and Tubing.Analytical methods : advancing methods and applications · 2015Article
- Microfluidic device with tunable post arrays and integrated electrodes for studying cellular release.The Analyst · 2014Article
- 3D printed microfluidic devices with integrated versatile and reusable electrodes.Lab on a chip · 2014Article
- Encapsulation of Fluidic Tubing and Microelectrodes in Microfluidic Devices: Integrating Off-Chip Process and Coupling Conventional Capillary Electrophoresis with Electrochemical Detection.Analytical methods : advancing methods and applications · 2013Article
- Encapsulated electrodes for microchip devices: microarrays and platinized electrodes for signal enhancement.Electrophoresis · 2013Article
- Microchip-based electrochemical detection for monitoring cellular systems.Analytical and bioanalytical chemistry · 2013Review
- Integration of microchip electrophoresis with electrochemical detection using an epoxy-based molding method to embed multiple electrode materials.Electrophoresis · 2011Article
- Use of epoxy-embedded electrodes to integrate electrochemical detection with microchip-based analysis systems.Electrophoresis · 2011Review
- Use of Recordable Compact Discs to Fabricate Electrodes for Microchip-based Analysis Systems.Analytical methods : advancing methods and applications · 2010Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
This paper describes the fabrication and characterization of thin-layer mercury/gold amalgam microelectrodes and their integration with microchip-based flow injection analysis. This microchip platform allows on-chip injection and lysis of erythrocytes followed by selective detection of intracellular glutathione (GSH) at low potentials. The thin-layer gold microelectrodes were amalgamated by electrodeposition of mercury. The electrodes produced a linear response for both GSH and cysteine in flow injection analysis studies utilizing both off-chip and on-chip injection. Comparative experiments using diamide and on-chip injection were performed to demonstrate the ability of the microchip device to detect changes in GSH concentration. Finally, rabbit erythrocyte samples (2% hematocrit) were injected and lysed on-chip and the amount of GSH detected corresponded to 312 amol/cell, which is in agreement with previously reported values. The selectivity, short time between injection and detection (approximately 5 s), and the continuous introduction of sample to the on-chip injector should enable the study of dynamically changing systems such as the glutathione redox system found in erythrocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.