ArticlePloS one2009
Rapid changes in transcription profiles of the Plasmodium yoelii yir multigene family in clonal populations: lack of epigenetic memory?
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Differential Trafficking and Expression of PIR Proteins in Acute and ChronicFrontiers in cellular and infection microbiology · 2022Article
- Analysis of pir gene expression across the Plasmodium life cycle.Malaria journal · 2021Article
- The spleen: "epicenter" in malaria infection and immunity.Journal of leukocyte biology · 2021Review
- Rapid activation of distinct members of multigene families in Plasmodium spp.Communications biology · 2020Article
- Host-Malaria Parasite Interactions and Impacts on Mutual Evolution.Frontiers in cellular and infection microbiology · 2020Review
- A glance of the blood stage transcriptome of a Southeast Asian Plasmodium ovale isolate.PLoS neglected tropical diseases · 2019Article
- Independent regulation of Plasmodium falciparum rif gene promoters.Scientific reports · 2018Article
- A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence.Nature communications · 2017Article
- Characterization of the Plasmodium Interspersed Repeats (PIR) proteins of Plasmodium chabaudi indicates functional diversity.Scientific reports · 2016Article
- Large, rapidly evolving gene families are at the forefront of host-parasite interactions in Apicomplexa.Parasitology · 2015Review
- Recruitment of PfSET2 by RNA polymerase II to variant antigen encoding loci contributes to antigenic variation in P. falciparum.PLoS pathogens · 2014Article
- Horizontal gene transfer of epigenetic machinery and evolution of parasitism in the malaria parasite Plasmodium falciparum and other apicomplexans.BMC evolutionary biology · 2013Article
- Remarkable stability in patterns of blood-stage gene expression during episodes of non-lethal Plasmodium yoelii malaria.Malaria journal · 2012Article
- Characterization and gene expression analysis of the cir multi-gene family of Plasmodium chabaudi chabaudi (AS).BMC genomics · 2012Article
- Expression and strain variation of the novel "small open reading frame" (smorf) multigene family in Babesia bovis.International journal for parasitology · 2012Article
- Characterization and tissue-specific expression patterns of the Plasmodium chabaudi cir multigene family.Malaria journal · 2011Article
- A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito.PLoS neglected tropical diseases · 2010Article
- Characterization of the repertoire diversity of the Plasmodium falciparum stevor multigene family in laboratory and field isolates.Malaria journal · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The pir multigene family, found in the genomes of Plasmodium vivax, P. knowlesi and the rodent malaria species, encode variant antigens that could be targets of the immune response. Individual parasites of the rodent malaria Plasmodium yoelii, selected by micromanipulation, transcribe only 1 to 3 different pir (yir) suggesting tight transcriptional control at the level of individual cells. Using microarray and quantitative RT-PCR, we show that despite this very restricted transcription in a single cell, many yir genes are transcribed throughout the intra-erythrocytic asexual cycle. The timing and level of transcription differs between genes, with some being more highly transcribed in ring and trophozoite stages, whereas others are more highly transcribed in schizonts. Infection of immunodeficient mice with single infected erythrocytes results in populations of parasites each with transcriptional profiles different from that of the parent parasite population and from each other. This drift away from the original 'set' of transcribed genes does not appear to follow a preset pattern and "epigenetic memory" of the yir transcribed in the parent parasite can be rapidly lost. Thus, regulation of pir gene transcription may be different from that of the well-characterised multigene family, var, of Plasmodium falciparum.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.