ArticlePhytotherapy research : PTR2009
Cranberry proanthocyanidins are cytotoxic to human cancer cells and sensitize platinum-resistant ovarian cancer cells to paraplatin.
Article in Phytotherapy research : PTR, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 69 citations in OpenAlex.
- Dietary polyphenols and human health: sources, biological activities, nutritional and immunological aspects, and bioavailability- a comprehensive review.Frontiers in immunology · 2025Review
- A Review with a Focus onPlants (Basel, Switzerland) · 2024Review
- Electrochemical determination of the procyanidins in peanut skin using a carbon nanotube electrode.Analytical sciences : the international journal of the Japan Society for Analytical Chemistry · 2024Article
- Phenolic Fractions fromAntioxidants (Basel, Switzerland) · 2020Article
- New Evidences of Antibacterial Effects of Cranberry Against Periodontal Pathogens.Foods (Basel, Switzerland) · 2020Article
- Cranberries and Cancer: An Update of Preclinical Studies Evaluating the Cancer Inhibitory Potential of Cranberry and Cranberry Derived Constituents.Antioxidants (Basel, Switzerland) · 2016Review
- Cranberry-derived proanthocyanidins impair virulence and inhibit quorum sensing of Pseudomonas aeruginosa.Scientific reports · 2016Article
- Effect of Procyanidin-rich Extract from Natural Cocoa Powder on Cellular Viability, Cell Cycle Progression, and Chemoresistance in Human Epithelial Ovarian Carcinoma Cell Lines.Pharmacognosy magazine · 2016Article
- The cranberry flavonoids PAC DP-9 and quercetin aglycone induce cytotoxicity and cell cycle arrest and increase cisplatin sensitivity in ovarian cancer cells.International journal of oncology · 2015Article
- Cranberry Flavonoids Modulate Cariogenic Properties of Mixed-Species Biofilm through Exopolysaccharides-Matrix Disruption.PloS one · 2015Article
- Procyanidins Negatively Affect the Activity of the Phosphatases of Regenerating Liver.PloS one · 2015Article
- The American cranberry: first insights into the whole genome of a species adapted to bog habitat.BMC plant biology · 2014Article
- Myristicyclins A and B: antimalarial procyanidins from Horsfieldia spicata from Papua New Guinea.Organic letters · 2014Article
- The first genetic map of the American cranberry: exploration of synteny conservation and quantitative trait loci.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Article
- Article
- Influence of cranberry proanthocyanidins on formation of biofilms by Streptococcus mutans on saliva-coated apatitic surface and on dental caries development in vivo.Caries research · 2010Article
- Addition of cranberry to proton pump inhibitor-based triple therapy forJournal of research in pharmacy practiceArticle
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Polyphenolic extracts of the principal flavonoid classes present in cranberry were screened in vitro for cytotoxicity against solid tumor cells lines, identifying two fractions composed principally of proanthocyanidins (PACs) with potential anticancer activity. Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF-MS) analysis of the proanthocyanidins (PACs) fractions indicated the presence of A-type PACs with 1-4 linkages containing between 2-8 epicatechin units with a maximum of 1 epigallocatechin unit. PACs exhibited in vitro cytotoxicity against platinum-resistant human ovarian, neuroblastoma and prostate cancer cell lines (IC50 = 79-479 microg/mL) but were non-cytotoxic to lung fibroblast cells (IC50 > 1000 microg/ml). SKOV-3 ovarian cancer cells treated with PACs exhibited classic apoptotic changes. PACs acted synergistically with paraplatin in SKOV-3 cells. Pretreatment of SKOV-3 cells with PACs (106 microg/ml) resulted in a significant reduction of the paraplatin IC50 value. Similarly, in a BrdU incorporation assay, co-treatment of SKOV-3 cells with PACs and paraplatin revealed reduced cell proliferation at lower concentrations than with either individually. In SKOV-3 cell cultures co-treated with PAC-1 and paraplatin, an HPLC analysis indicated differential quantitative presence of various PAC oligomers such as DP-8, -9, -11 and -14 indicating either selective binding or uptake. Cranberry proanthocyanidins exhibit cell-line specific cytotoxicity, induce apoptotic markers and augment cytotoxicity of paraplatin in platinum-resistant SKOV-3 ovarian cancer cells.
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Registered trials
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