ArticleMarine drugs2008
Characterizing the anti-HIV activity of papuamide A.
Article in Marine drugs, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Unlocking the potential: Exploring the application of bioactive peptides in aquaculture.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases.Marine drugs · 2022Review
- Antiviral Peptides (AVPs) of Marine Origin as Propitious Therapeutic Drug Candidates for the Treatment of Human Viruses.Molecules (Basel, Switzerland) · 2022Review
- Marine natural products targeting the eukaryotic cell membrane.The Journal of antibiotics · 2021Review
- Swinhopeptolides A and B: Cyclic Depsipeptides from the SpongeJournal of natural products · 2020Article
- The Lipid Flippases ALA4 and ALA5 Play Critical Roles in Cell Expansion and Plant Growth.Plant physiology · 2020Article
- The wheat ABC transporter Lr34 modifies the lipid environment at the plasma membrane.The Journal of biological chemistry · 2018Article
- Marine natural product peptides with therapeutic potential: Chemistry, biosynthesis, and pharmacology.Biochimica et biophysica acta. General subjects · 2018Review
- Antiviral activity of animal venom peptides and related compounds.The journal of venomous animals and toxins including tropical diseases · 2017Review
- Digital detection of endonuclease mediated gene disruption in the HIV provirus.Scientific reports · 2016Article
- SB-224289 Antagonizes the Antifungal Mechanism of the Marine Depsipeptide Papuamide A.PloS one · 2016Article
- Role of Marine Natural Products in the Genesis of Antiviral Agents.Chemical reviews · 2015Review
- Marine peptides and their anti-infective activities.Marine drugs · 2015Review
- 4-Quinolone alkaloids from Melochia odorata.Journal of natural products · 2014Article
- Natural products from the Lithistida: a review of the literature since 2000.Marine drugs · 2011Review
- The Lithistida: important sources of compounds useful in biomedical research.Current opinion in biotechnology · 2010Review
- Potential anti-HIV agents from marine resources: an overview.Marine drugs · 2010Review
- Antiviral lead compounds from marine sponges.Marine drugs · 2010Review
- Cyclodepsipeptides from marine sponges: natural agents for drug research.Marine drugs · 2010Article
- Human skin permeation of emerging mycotoxins (beauvericin and enniatins).Journal of exposure science & environmental epidemiologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 2 countries.
Funding
Abstract
Papuamide A is representative of a class of marine derived cyclic depsipeptides, reported to have cytoprotective activity against HIV-1 in vitro. We show here that papuamide A acts as an entry inhibitor, preventing human immunodeficiency virus infection of host cells and that this inhibition is not specific to R5 or X4 tropic virus. This inhibition of viral entry was determined to not be due to papuamide A binding to CD4 or HIV gp120, the two proteins involved in the cell-virus recognition and binding. Furthermore, papuamide A was able to inhibit HIV pseudotype viruses expressing envelope glycoproteins from vesicular stomatitis virus or amphotropic murine leukemia virus indicating the mechanism of viral entry inhibition is not HIV-1 envelope glycoprotein specific. Time delayed addition studies with the pseudotyped viruses show that papuamide A inhibits viral infection only at the initial stage of the viral life cycle. Additionally, pretreatment studies revealed that the virus, and not the cell, is the target of papuamide A's action. Together, these results suggest a direct virucidal mechanism of HIV-1 inhibition by papuamide A. We also demonstrate here that the other papuamides (B-D) are able to inhibit viral entry indicating that the free amino moiety of 2,3-diaminobutanoic acid residue is not required for the virucidal activity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.