ArticlePloS one2009
Requirement for abasic endonuclease gene homologues in Arabidopsis seed development.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Molecular mechanisms and biological functions of active DNA demethylation in plants.Epigenetics & chromatin · 2025Review
- A new Caenorhabditis elegans apurinic/apyrimidinic (AP) endonuclease engaged in rescue from replication stress-induced arrest.Genetics and molecular biology · 2025Article
- Base Excision DNA Repair in Plants:International journal of molecular sciences · 2023Review
- Functional importance and divergence of plant apurinic/apyrimidinic endonucleases in somatic and meiotic DNA repair.The Plant cell · 2023Article
- DNA Base Excision Repair in Plants: An Unfolding Story With Familiar and Novel Characters.Frontiers in plant science · 2019Review
- Article
- APURINIC/APYRIMIDINIC ENDONUCLEASE2 and ZINC FINGER DNA 3'-PHOSPHOESTERASE Play Overlapping Roles in the Maintenance of Epigenome and Genome Stability.The Plant cell · 2018Article
- Nonenzymatic release of N7-methylguanine channels repair of abasic sites into an AP endonuclease-independent pathway inProceedings of the National Academy of Sciences of the United States of America · 2018Article
- Protecting DNA from errors and damage: an overview of DNA repair mechanisms in plants compared to mammals.Cellular and molecular life sciences : CMLS · 2017Review
- An AP endonuclease functions in active DNA demethylation and gene imprinting in Arabidopsis [corrected].PLoS genetics · 2015Article
- AP endonucleases process 5-methylcytosine excision intermediates during active DNA demethylation in Arabidopsis.Nucleic acids research · 2014Article
- Cloning and characterization of a wheat homologue of apurinic/apyrimidinic endonuclease Ape1L.PloS one · 2014Article
- Genotoxic stress and DNA repair in plants: emerging functions and tools for improving crop productivity.Plant cell reports · 2011Review
- Integrated functional networks of process, tissue, and developmental stage specific interactions in Arabidopsis thaliana.BMC systems biology · 2010Article
- DNA repair and recombination in higher plants: insights from comparative genomics of Arabidopsis and rice.BMC genomics · 2010Article
- Function and molecular mechanisms of APE2 in genome and epigenome integrity.Mutation research. Reviews in mutation researchReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arabidopsis thaliana has three genes, Ape1L, Ape2, and Arp, that show homology to abasic (apurinic/apyrimidinic) endonuclease genes of bacterial, yeast, or animal cells. In bacteria, yeast, and animals, abasic endonucleases function in base excision repair of oxidized and other modified DNA bases. Here we report that plants with knock-out mutations in any one of Ape1L, Ape2, or Arp show no apparent differences from wild type in growth rate, growth habit, and fertility. However, coincident knock-out mutations in Ape1L and Ape2 are lethal and lead to abortion of developing embryos. Mutations of Arp are not deleterious, even in combination with one of the other two mutations. The results are consistent with the interpretation that the process of base excision repair, involving at least one intact copy of Ape1L or Ape2, is required in the process of embryogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.