ArticleProceedings of the National Academy of Sciences of the United States of America2009
Nodal points and complexity of Notch-Ras signal integration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- Multiview representation learning for identification of novel cancer genes and their causative biological mechanisms.Briefings in bioinformatics · 2024Article
- Phosphorylation of Suppressor of Hairless impedes its DNA-binding activity.Scientific reports · 2017Article
- Mapping signaling pathway cross-talk in Drosophila cells.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- The Notch-mediated hyperplasia circuitry in Drosophila reveals a Src-JNK signaling axis.eLife · 2015Article
- Article
- Notch directly regulates the cell morphogenesis genes Reck, talin and trio in adult muscle progenitors.Journal of cell science · 2014Article
- Spatial and temporal organization of signaling pathways.Trends in biochemical sciences · 2014Review
- Whole genome sequencing of Ethiopian highlanders reveals conserved hypoxia tolerance genes.Genome biology · 2014Article
- Transcriptional dynamics elicited by a short pulse of notch activation involves feed-forward regulation by E(spl)/Hes genes.PLoS genetics · 2013Article
- The Notch signalling system: recent insights into the complexity of a conserved pathway.Nature reviews. Genetics · 2012Review
- Vascular endothelial growth factor A, secreted in response to transforming growth factor-β1 under hypoxic conditions, induces autocrine effects on migration of prostate cancer cells.Asian journal of andrology · 2012Article
- Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila.The EMBO journal · 2012Article
- Signaling in cell differentiation and morphogenesis.Cold Spring Harbor perspectives in biology · 2012Review
- Notch signaling is necessary to maintain quiescence in adult muscle stem cells.Stem cells (Dayton, Ohio) · 2012Article
- Genome-wide identification of possible methylation markers chemosensitive to targeted regimens in colorectal cancers.Journal of cancer research and clinical oncology · 2011Article
- Trp53 regulates Notch 4 signaling through Mdm2.Journal of cell science · 2011Article
- Human stem/progenitor cells from bone marrow enhance glial differentiation of rat neural stem cells: a role for transforming growth factor β and Notch signaling.Stem cells and development · 2011Article
- Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells.Cancer cell · 2010Article
- RETRACTED: Molecular structure and dimeric organization of the Notch extracellular domain as revealed by electron microscopy.PloS one · 2010Article
- Article
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Authors and funding
3 authors.
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Abstract
Metazoans use a handful of highly conserved signaling pathways to create a signaling backbone that governs development. How these few signals have such a versatile action likely depends upon the larger-scale network they form through integration, as exemplified by cross-talk between the Notch and receptor tyrosine kinase (RTK) pathways. We examined the transcriptional output of Notch-RTK cross-talk during Drosophila development and present in vivo data supporting a role for selected mutually regulated genes in signal integration. Interestingly, Notch-RTK integration did not lead to general antagonism of either pathway, as is commonly believed. Instead, integration had a combinatorial effect on specific cross-regulated targets, which unexpectedly included numerous core components of the RTK and other major signaling pathways (TGF-beta, Hh, Jak/Stat, nuclear receptor and Wnt). We find the majority of Ras-responsive genes are also Notch-responsive, suggesting Notch may function to specify the response to Ras activation.
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