ArticleAntimicrobial agents and chemotherapy2009
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
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- The anti-staphylococcal fusidic acid as an efflux pump inhibitor combined with fluconazole against vaginal candidiasis in mouse model.BMC microbiology · 2024Article
- A review of the fernane-type triterpenoids as anti-fungal drugs.Frontiers in pharmacology · 2024Review
- Screening the Tocriscreen™ bioactive compound library in search for inhibitors of Candida biofilm formation.APMIS : acta pathologica, microbiologica, et immunologica Scandinavica · 2022Article
- Synergistic Interactions of Schizostatin Identified fromThe plant pathology journal · 2020Article
- Total alkaloids ofChinese herbal medicines · 2020Article
- Teasaponin suppressesAnnals of translational medicine · 2020Article
- Anticancer Potential of Lichens' Secondary Metabolites.Biomolecules · 2020Review
- Anticandidal Activity of Kalopanaxsaponin A: Effect on Proliferation, Cell Morphology, and Key Virulence Attributes ofFrontiers in microbiology · 2019Article
- Enfumafungin synthase represents a novel lineage of fungal triterpene cyclases.Environmental microbiology · 2018Article
- Article
- The Kallikrein-Kinin System: A Novel Mediator of IL-17-Driven Anti-Candida Immunity in the Kidney.PLoS pathogens · 2016Article
- Thymol has antifungal activity against Candida albicans during infection and maintains the innate immune response required for function of the p38 MAPK signaling pathway in Caenorhabditis elegans.Immunologic research · 2016Article
- A combination approach to treating fungal infections.Scientific reports · 2015Article
- Effects of magnolol and honokiol on adhesion, yeast-hyphal transition, and formation of biofilm by Candida albicans.PloS one · 2015Article
- Synergistic combinations of antifungals and anti-virulence agents to fight against Candida albicans.Virulence · 2015Review
- Statins and Antimicrobial Effects: Simvastatin as a Potential Drug against Staphylococcus aureus Biofilm.PloS one · 2015Article
- Synergistic antifungal effect of glabridin and fluconazole.PloS one · 2014Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vitro antifungal activity of retigeric acid B (RAB), a pentacyclic triterpenoid from the lichen species Lobaria kurokawae, was evaluated alone and in combination with fluconazole, ketoconazole, and itraconazole against Candida albicans using checkerboard microdilution and time-killing tests. The MICs for RAB against 10 different C. albicans isolates ranged from 8 to 16 microg/ml. A synergistic action of RAB and azole was observed in azole-resistant strains, whereas synergistic or indifferent effects were observed in azole-sensitive strains when interpreted by a separate approach of the fractional inhibitory concentration index and DeltaE model (the difference between the predicted and measured fungal growth percentages). In time-killing tests, we used both colony counts and a colorimetric assay to evaluate the combinational antifungal effects of RAB and azoles, which further confirmed their synergistic interactions. These findings suggest that the natural product RAB may play a certain role in increasing the susceptibilities of azole-resistant C. albicans strains.
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