ArticleAntimicrobial agents and chemotherapy2009
Mutations in three distinct loci cause resistance to peptide deformylase inhibitors in Bacillus subtilis.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Unraveling the Prevalence and Multifaceted Roles of Accessory Peptide Deformylases in Bacterial Adaptation and Resistance.Molecular biology and evolution · 2025Article
- System-wide analyses reveal essential roles of N-terminal protein modification in bacterial membrane integrity.iScience · 2022Article
- Lack of formylated methionyl-tRNA has pleiotropic effects on Bacillus subtilis.Microbiology (Reading, England) · 2017Article
- Characterization and evaluation of antimicrobial activity of actinonin against foodborne pathogens.Food science and biotechnology · 2017Article
- A unique peptide deformylase platform to rationally design and challenge novel active compounds.Scientific reports · 2016Article
- The Inhibition and Resistance Mechanisms of Actinonin, Isolated from Marine Streptomyces sp. NHF165, against Vibrio anguillarum.Frontiers in microbiology · 2016Article
- Frequency of Spontaneous Resistance to Peptide Deformylase Inhibitor GSK1322322 in Haemophilus influenzae, Staphylococcus aureus, Streptococcus pyogenes, and Streptococcus pneumoniae.Antimicrobial agents and chemotherapy · 2015Article
- Staphylococcus aureus formyl-methionyl transferase mutants demonstrate reduced virulence factor production and pathogenicity.Antimicrobial agents and chemotherapy · 2013Article
- Article
- Regulation of translation by one-carbon metabolism in bacteria and eukaryotic organelles.The Journal of biological chemistryReview
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Authors and funding
3 authors.
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Abstract
Bacillus subtilis mutants with resistance against peptide deformylase inhibitors were isolated. All showed a bypass of the pathway through mutations in three genes required for formylation of Met-tRNA(fMet), fmt, folD, and glyA. glyA corresponds to a yet uncharacterized locus inducing resistance. The bypass of formylation caused robust fitness reduction but was not accompanied by alterations of the transcription profile. A subtle adaptation of the enzymes of the intermediary metabolism was observed.
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