ReviewExperimental neurology2009
Functional imaging in Huntington's disease.
Review in Experimental neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
43 citing papers in PubMed, 2 syntheses or guidelines pooled it, 109 citations in OpenAlex.
- Functional connectivity modeling of consistent cortico-striatal degeneration in Huntington's disease.NeuroImage. Clinical · 2015Pooled it
- The centre of the brain: topographical model of motor, cognitive, affective, and somatosensory functions of the basal ganglia.Human brain mapping · 2013Pooled it
- Progressively reduced cerebral oxygen metabolism and elevated plasma NfL levels in the zQ175DN mouse model of Huntington's disease.Experimental neurology · 2025Article
- Striato-cortical connectivity patterns predict clinical profiles in Huntington's disease.NeuroImage. Clinical · 2025Article
- The contribution of preclinical magnetic resonance imaging and spectroscopy to Huntington's disease.Frontiers in aging neuroscience · 2024Review
- Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model.Neurobiology of disease · 2023Article
- Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model.bioRxiv : the preprint server for biology · 2023Article
- Huntingtin silencing delays onset and slows progression of Huntington's disease: a biomarker study.Brain : a journal of neurology · 2021Article
- Impaired response of cerebral oxygen metabolism to visual stimulation in Huntington's disease.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2021Article
- Fixel-Based Analysis Effectively Identifies White Matter Tract Degeneration in Huntington's Disease.Frontiers in neuroscience · 2021Article
- Working Memory-Related Effective Connectivity in Huntington's Disease Patients.Frontiers in neurology · 2018Article
- Neuroimaging in Dementia.Seminars in neurology · 2017Review
- Microstructural Abnormalities of Basal Ganglia and Thalamus in Bipolar and Unipolar Disorders: A Diffusion Kurtosis and Perfusion Imaging Study.Psychiatry investigation · 2017Article
- Resting-state connectivity and modulated somatomotor and default-mode networks in Huntington disease.CNS neuroscience & therapeutics · 2017Article
- Striatal hypometabolism in premanifest and manifest Huntington's disease patients.European journal of nuclear medicine and molecular imaging · 2016Article
- The Allure of High-Risk Rewards in Huntington's disease.Journal of the International Neuropsychological Society : JINS · 2016Article
- The role of the amygdala during emotional processing in Huntington's disease: from pre-manifest to late stage disease.Neuropsychologia · 2015Article
- Neurophysiological and neurocognitive mechanisms underlying the effects of yoga-based practices: towards a comprehensive theoretical framework.Frontiers in human neuroscience · 2015Article
- Striatal metabolism and psychomotor speed as predictors of motor onset in Huntington's disease.Journal of neurology · 2014Article
- Frontal cortex BOLD signal changes in premanifest Huntington disease: a possible fMRI biomarker.Neurology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Huntington's disease (HD) is a genetic brain disease characterized by loss of capacity in movement control, cognition, and emotional regulation over a period of about 30 years. Since it is well established that clinical impairments and brain atrophy can be detected decades prior to receiving a clinical diagnosis, functional neuroimaging efforts have gained momentum in HD research. In most brain disorders, there is accumulating evidence that the clinical manifestations of disease do not simply depend on the extent of tissue loss, but represent a complex balance among neuronal dysfunction, tissue repair, and circuitry reorganization. Based upon this premise, functional neuroimaging modalities may be more sensitive to the earliest changes in HD than are structural imaging approaches. For this review, PET and fMRI studies conducted in HD samples were summarized. Strengths and limitations of the utilization of functional imaging in HD are discussed and recommendations are offered to facilitate future research endeavors.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.