ReviewCurrent rheumatology reports2009
WNT Signaling in osteoarthritis and osteoporosis: what is the biological significance for the clinician?
Review in Current rheumatology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Multi-omics analysis of histidine metabolism reveals FRZB-CRYM-associated cellular crosstalk in heart failure.Frontiers in cardiovascular medicine · 2026Article
- Molecular Biology of ACL Graft Healing: Early Mechanical Loading Perspective.Orthopedic reviews · 2025Article
- Parathyroid hormone (1-34) retards the lumbar facet joint degeneration and activates Wnt/β-catenin signaling pathway in ovariectomized rats.Journal of orthopaedic surgery and research · 2024Article
- WTAP-mediated mExperimental & molecular medicine · 2024Article
- Mapping knowledge landscapes and emerging trends of the links between osteoarthritis and osteoporosis: A bibliometric analysis.Frontiers in public health · 2022Article
- MicroRNA-1 Modulates Chondrocyte Phenotype by Regulating FZD7 of Wnt/ β-Catenin Signaling Pathway.Cartilage · 2021Article
- Observational
- A long non-coding RNA, HOTAIR, promotes cartilage degradation in osteoarthritis by inhibiting WIF-1 expression and activating Wnt pathway.BMC molecular and cell biology · 2020Article
- Electrospun Polymers in Cartilage Engineering-State of Play.Frontiers in bioengineering and biotechnology · 2020Review
- Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.PloS one · 2017Article
- The Expression of Osteopontin and Wnt5a in Articular Cartilage of Patients with Knee Osteoarthritis and Its Correlation with Disease Severity.BioMed research international · 2016Article
- Diametrical diseases reflect evolutionary-genetic tradeoffs: Evidence from psychiatry, neurology, rheumatology, oncology and immunology.Evolution, medicine, and public health · 2015Review
- Interplay between cartilage and subchondral bone contributing to pathogenesis of osteoarthritis.International journal of molecular sciences · 2013Review
- Characterization of microRNA expression profiles in normal and osteoarthritic human chondrocytes.BMC musculoskeletal disorders · 2012Article
- Osteoarthritis as a whole joint disease.HSS journal : the musculoskeletal journal of Hospital for Special Surgery · 2012Article
- Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice.Arthritis research & therapy · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoporosis and osteoarthritis are common musculoskeletal disorders in which cause and outcome are determined by genetic and environmental factors. The WNT signaling pathway plays an important role in skeletal development and growth. Polymorphisms in a number of genes that belong to this pathway are associated with osteoarthritis and/or osteoporosis. This suggests a role for this molecular signaling pathway in postnatal joint and bone homeostasis and pathology. Increased activity of WNT signaling strengthens the bone but may have adverse effects on the articular cartilage. Frizzled related protein (FRZB) plays a role in both bone and cartilage. Better understanding of the WNT pathway and its modulators may lead to specific therapeutics for both osteoarthritis and osteoporosis. This review focuses on recent studies in human genetics and animal models and highlights the potential clinical relevance of this rapidly evolving field of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.