ArticleJournal of biology2009
A circuit supporting concentration-invariant odor perception in Drosophila.
Article in Journal of biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
87 citing papers in PubMed, 161 citations in OpenAlex.
- Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Order code in the olfactory system.bioRxiv : the preprint server for biology · 2025Article
- Article
- Article
- Imaging different cell populations in the mouse olfactory bulb using the genetically encoded voltage indicator ArcLight.Neurophotonics · 2024Review
- Common principles for odour coding across vertebrates and invertebrates.Nature reviews. Neuroscience · 2024Review
- The subapical labial sensory organ of spotted lanternflyOpen biology · 2024Article
- Cross-talk between immunity and behavior: insights from entomopathogenic fungi and their insect hosts.FEMS microbiology reviews · 2024Review
- Review
- Normative and mechanistic model of an adaptive circuit for efficient encoding and feature extraction.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Gain modulation and odor concentration invariance in early olfactory networks.PLoS computational biology · 2023Article
- Multielectrode recordings of cockroach antennal lobe neurons in response to temporal dynamics of odor concentrations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- Stability of olfactory behavior syndromes in the Drosophila larva.Scientific reports · 2023Article
- Mushroom body output neurons MBON-a1/a2 define an odor intensity channel that regulates behavioral odor discrimination learning in larvalFrontiers in physiology · 2023Article
- Identification of a GABAergic neuroblast lineage modulating sweet and bitter taste sensitivity.Current biology : CB · 2022Article
- Depolarization block in olfactory sensory neurons expands the dimensionality of odor encoding.Science advances · 2022Article
- The chemosensory system of theFly · 2022Review
- Article
- Adaptive temporal processing of odor stimuli.Cell and tissue research · 2021Review
- Localized inhibition in theeLife · 2020Article
27 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMost odors are perceived to have the same quality over a large concentration range, but the neural mechanisms that permit concentration-invariant olfactory perception are unknown. In larvae of the vinegar fly Drosophila melanogaster, odors are sensed by an array of 25 odorant receptors expressed in 21 olfactory sensory neurons (OSNs). We investigated how subsets of larval OSNs with overlapping but distinct response properties cooperate to mediate perception of a given odorant across a range of concentrations.
resultsUsing calcium imaging, we found that ethyl butyrate, an ester perceived by humans as fruity, activated three OSNs with response thresholds that varied across three orders of magnitude. Whereas wild-type larvae were strongly attracted by this odor across a 500-fold range of concentration, individuals with only a single functional OSN showed attraction across a narrower concentration range corresponding to the sensitivity of each ethyl butyrate-tuned OSN. To clarify how the information carried by different OSNs is integrated by the olfactory system, we characterized the response properties of local inhibitory interneurons and projection neurons in the antennal lobe. Local interneurons only responded to high ethyl butyrate concentrations upon summed activation of at least two OSNs. Projection neurons showed a reduced response to odors when summed input from two OSNs impinged on the circuit compared to when there was only a single functional OSN.
conclusionsOur results show that increasing odor concentrations induce progressive activation of concentration-tuned olfactory sensory neurons and concomitant recruitment of inhibitory local interneurons. We propose that the interplay of combinatorial OSN input and local interneuron activation allows animals to remain sensitive to odors across a large range of stimulus intensities.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.