ArticleThe journal of sexual medicine2009
Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation.
Article in The journal of sexual medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers, 5 of them syntheses that pooled it.
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Who cites it
52 citing papers in PubMed, 5 syntheses or guidelines pooled it, 215 citations in OpenAlex.
- Management of premature ejaculation: a clinical guideline from the Italian Society of Andrology and Sexual Medicine (SIAMS).Journal of endocrinological investigation · 2021Guideline
- Pooled it
- Pooled it
- Efficacy and safety of local anaesthetics for premature ejaculation: a systematic review and meta-analysis.Asian journal of andrology · 2013Pooled it
- Pooled it
- Effects of paroxetine on intravaginal ejaculatory latency time in Egyptian patients with lifelong premature ejaculation as a function of serotonin transporter polymorphism.International journal of impotence research · 2017Trial
- Sexual dysfunction during treatment with serotonergic and noradrenergic antidepressants: clinical description and the role of the 5-HTTLPR.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2011Trial
- Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios in primary versus secondary premature ejaculation: a comparative study.Basic and clinical andrology · 2026Article
- British Society for Sexual Medicine (BSSM) Position Statement on Premature Ejaculation.The world journal of men's health · 2025Review
- Possible Pathophysiological Roles of Neurotransmitter Systems in Men With Lifelong Premature Ejaculation: Protocol for a Scoping Review.JMIR research protocols · 2023Article
- Current and emerging treatment options for premature ejaculation.Nature reviews. Urology · 2022Review
- Association between 5-HTTLPR and STin2 VNTR polymorphisms in the serotonin transporter gene and clinical response of a selective serotonin reuptake inhibitor (dapoxetine) in lifelong premature ejaculation.Chinese medical journal · 2022Article
- Lifelong Premature Ejaculation and Attention-Deficit Hyperactivity Disorder: A Controlled Study.Alpha psychiatry · 2022Article
- Genome-Wide Association Analysis to Search for New Loci Associated with Lifelong Premature Ejaculation Risk in Chinese Male Han Population.The world journal of men's health · 2022Article
- Article
- [Premature ejaculation (ejaculatio praecox) in adult men : Selective serotonin re-uptake inhibitors].Der Urologe. Ausg. A · 2021Article
- A bibliometric analysis of international publication trends in premature ejaculation research (2008-2018).International journal of impotence research · 2021Article
- Role of Yoga in the Management of Premature Ejaculation.The world journal of men's health · 2020Review
- Association between 5-hydroxytryptamine transporter gene-linked promoter region polymorphism and the susceptibility of lifelong premature ejaculation: a meta-analysis involving 1,604 subjects.Translational andrology and urology · 2020Review
- Brain Cortical Complexity and Subcortical Morphometrics in Lifelong Premature Ejaculation.Frontiers in human neuroscience · 2020Article
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Authors and funding
7 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionLifelong premature ejaculation (LPE) is characterized by persistent intravaginal ejaculation latency times (IELTs) of less than 1 minute, and has been postulated as a neurobiological dysfunction with genetic vulnerability for the short IELTs, related to disturbances of central serotonin (5-hydroxytryptamine [5-HT]) neurotransmission and 5-HT receptor functioning.
aimTo investigate the relationship between 5-HT transporter gene-linked polymorphism (5-HTTLPR) and short IELTs in men with lifelong PE.
methodsA prospective study was conducted in 89 Dutch Caucasian men with lifelong PE. IELT during coitus was assessed by stopwatch over a 1-month period. Controls consisted of 92 Dutch Caucasian men. All men with LPE were genotyped for a 5-HTT-promoter polymorphism. Allele frequencies and genotypes of short (S) and long (L) variants of 5-HTTLPR polymorphism were compared between patients and controls. Association between LL, SL, and SS genotypes, and the natural logarithm of the IELT in men with LPE was investigated.
main outcome measuresIELT measured by stopwatch, 5-HTTLPR polymorphism.
resultsIn men with lifelong PE, the geometric mean, median, and natural mean IELTs were 21, 26, and 32 seconds, respectively. There were no significant differences in the 5-HTT polymorphism alleles and genotypes between 89 Dutch Caucasian men with LPE (S 47%, L 53%/LL 29%, SL 48%, SS 22%) and 92 Dutch Caucasian controls (S 48%, L 52%/LL 29%, SL 45%, SS 26%). In men with lifelong PE there was a statistically significant difference between LL, SL, and SS genotypes in their geometric mean IELT (P < or = 0.027); the LL genotypes had significantly shorter IELTs than the SS and SL genotypes.
conclusionsThe 5-HTTLPR polymorphism is associated with significant effects on the latency to ejaculate in men with lifelong PE. Men with SS and SL genotypes have 100% and 90% longer ejaculation time, respectively than men with LL genotypes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.