ArticleAlcoholism, clinical and experimental research2009
Quantitative lipid metabolomic changes in alcoholic micropigs with fatty liver disease.
Article in Alcoholism, clinical and experimental research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Methionine metabolism, functions, and application in swine.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025Review
- Review
- Preparation of Active Peptides fromMolecules (Basel, Switzerland) · 2022Article
- DNA Methylation in Nonalcoholic Fatty Liver Disease.International journal of molecular sciences · 2020Review
- Metabolomic and Lipidomic Biomarkers for Premalignant Liver Disease Diagnosis and Therapy.Metabolites · 2020Review
- Lipid Droplet Fusion in Mammary Epithelial Cells is Regulated by Phosphatidylethanolamine Metabolism.Journal of mammary gland biology and neoplasia · 2017Article
- Molecular Pathogenesis of NASH.International journal of molecular sciences · 2016Review
- Potential epigenetic mechanism in non-alcoholic Fatty liver disease.International journal of molecular sciences · 2015Review
- The metabolomic window into hepatobiliary disease.Journal of hepatology · 2013Review
- Strategies to rescue steatotic livers before transplantation in clinical and experimental studies.World journal of gastroenterology · 2013Review
- Chronic alcohol ingestion increases mortality and organ injury in a murine model of septic peritonitis.PloS one · 2013Article
- Altered hepatic retinyl ester concentration and acyl composition in response to alcohol consumption.Biochimica et biophysica acta · 2012Article
- Identification of N-acetyltaurine as a novel metabolite of ethanol through metabolomics-guided biochemical analysis.The Journal of biological chemistry · 2012Article
- Nutritional deficiencies and phospholipid metabolism.International journal of molecular sciences · 2011Review
- Metabolomics for assessment of nutritional status.Current opinion in clinical nutrition and metabolic care · 2009Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundChronic ethanol consumption coupled with folate deficiency leads to rapid liver fat accumulation and progression to alcoholic steatohepatitis (ASH). However, the specific effects of alcohol on key liver lipid metabolic pathways involved in fat accumulation are unknown. It is unclear whether lipid synthesis, lipid export, or a combination of both is contributing to hepatic steatosis in ASH.
methodsIn this study we estimated the flux of fatty acids (FA) through the stearoyl-CoA desaturase (SCD), phosphatidylethanolamine-N-methyltransferase (PEMT), and FA elongation pathways in relation to liver triacylglycerol (TG) content in Yucatan micropigs fed a 40% ethanol folate-deficient diet with or without supplementation with S-adenosyl methionine (SAM) compared with controls. Flux through the SCD and PEMT pathways was used to assess the contribution of lipid synthesis and lipid export respectively on the accumulation of fat in the liver. Liver FA composition within TG, cholesterol ester (CE), phosphatidylethanolamine, and phosphatidylcholine classes was quantified by gas chromatography.
resultsAlcoholic pigs had increased liver TG content relative to controls, accompanied by increased flux through the SCD pathway as indicated by increases in the ratios of 16:1n7 to 16:0 and 18:1n9 to 18:0. Conversely, flux through the elongation and PEMT pathways was suppressed by alcohol, as indicated by multiple metabolite ratios. SAM supplementation attenuated the TG accumulation associated with alcohol.
conclusionsThese data provide an in vivo examination of liver lipid metabolic pathways confirming that both increased de novo lipogenesis (e.g., lipid synthesis) and altered phospholipid metabolism (e.g., lipid export) contribute to the excessive accumulation of lipids in liver affected by ASH.
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