ArticleBehavioral neuroscience2009
Acquired appetitive responding to intravenous nicotine reflects a Pavlovian conditioned association.
Article in Behavioral neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 21 citations in OpenAlex.
- Cigarette Smoke Extract and Nicotine Evoke Similar Interoceptive Effects in a Pavlovian Occasion Setting Task in Male and Female Sprague-Dawley Rats.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026Article
- The inside story: Interoceptive Pavlovian conditioning with the nicotine stimulus.Journal of experimental psychology. Animal learning and cognition · 2025Review
- Pavlovian conditioning with the internal stimulus effects of intravenous nicotine heightens later nicotine taking with variation by dose and sex.Scientific reports · 2025Article
- Use of the overexpectation effect to reduce conditioned seeking behavior controlled by nicotine.Psychonomic bulletin & review · 2024Article
- Drug memory reconsolidation: from molecular mechanisms to the clinical context.Translational psychiatry · 2023Review
- Appetitive Pavlovian conditioning of the stimulus effects of nicotine enhances later nicotine self-administration.Journal of the experimental analysis of behavior · 2022Article
- Inactivation of posterior but not anterior dorsomedial caudate-putamen impedes learning with self-administered nicotine stimulus in male rats.Behavioural brain research · 2021Article
- Conditioned enhancement of the nicotine reinforcer.Experimental and clinical psychopharmacology · 2021Article
- Effects of nicotine conditioning history on alcohol and methamphetamine self-administration in rats.Pharmacology, biochemistry, and behavior · 2019Article
- The effect of sazetidine-A and other nicotinic ligands on nicotine controlled goal-tracking in female and male rats.Neuropharmacology · 2017Article
- The effect of switching pharmacological intervention during extinction on nicotine-evoked conditioned responding in rats.Psychopharmacology · 2015Article
- Interoceptive conditioning in rats: effects of using a single training dose or a set of 5 different doses of nicotine.Pharmacology, biochemistry, and behavior · 2013Article
- Excitatory conditioning to the interoceptive nicotine stimulus blocks subsequent conditioning to an exteroceptive light stimulus.Behavioural brain research · 2011Article
- Nicotine competes with a visual stimulus for control of conditioned responding.Addiction biology · 2011Article
- Extinction with varenicline and nornicotine, but not ABT-418, weakens conditioned responding evoked by the interoceptive stimulus effects of nicotine.Neuropharmacology · 2010Article
- Mecamylamine, dihydro-beta-erythroidine, and dextromethorphan block conditioned responding evoked by the conditional stimulus effects of nicotine.Pharmacology, biochemistry, and behavior · 2009Article
- Neuropharmacology of the interoceptive stimulus properties of nicotine.Current drug abuse reviews · 2009Review
- Nicotine-evoked conditioned responding is dependent on concentration of sucrose unconditioned stimulus.Behavioural processes · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Recent research examining Pavlovian appetitive conditioning has extended the associative properties of nicotine from the unconditioned stimulus or reward to include the role of a conditional stimulus (CS), capable of acquiring the ability to evoke a conditioned response. To date, published research has used presession extravascular injections to examine nicotine as a contextual CS in that appetitive Pavlovian drug discrimination task. Two studies in the current research examined whether a nicotine CS can function discretely, multiple times within a session using passive iv infusions. In Experiment 1, rats readily acquired a discrimination in conditioned responding between nicotine and saline infusions when nicotine was selectively paired with sucrose presentations. In Experiment 2, rats were either trained with nicotine paired with sucrose or explicitly unpaired with sucrose. The results showed that rats trained with explicitly unpaired nicotine and sucrose did not increase dipper entries after the infusions. Nicotine was required to be reliably paired with sucrose for control of conditioned responding to develop. Implications of these findings are discussed in relation to tobacco addiction, learning theory, and pharmacology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.