ArticleBehavioral neuroscience2009
Eyeblink conditioning during an interstimulus interval switch in rabbits (Oryctolagus cuniculus) using picrotoxin to disrupt cerebellar cortical input to the interpositus nucleus.
Article in Behavioral neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 21 citations in OpenAlex.
- Cerebellar secretin modulates eyeblink classical conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Differential effects of the cannabinoid agonist WIN55,212-2 on delay and trace eyeblink conditioning.Behavioral neuroscience · 2013Article
- Neonatal ethanol exposure results in dose-dependent impairments in the acquisition and timing of the conditioned eyeblink response and altered cerebellar interpositus nucleus and hippocampal CA1 unit activity in adult rats.Alcohol (Fayetteville, N.Y.) · 2013Article
- Cerebellar structure and function in male Wistar-Kyoto hyperactive rats.Behavioral neuroscience · 2013Article
- Translational approach to behavioral learning: lessons from cerebellar plasticity.Neural plasticity · 2013Review
- Anatomical characterization of a rabbit cerebellar eyeblink premotor pathway using pseudorabies and identification of a local modulatory network in anterior interpositus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Evaluation of bidirectional interstimulus interval (ISI) shift in auditory delay eye-blink conditioning in healthy humans.Learning & behavior · 2011Article
- Neural circuitry and plasticity mechanisms underlying delay eyeblink conditioning.Learning & memory (Cold Spring Harbor, N.Y.) · 2011Review
- Electrophysiological localization of eyeblink-related microzones in rabbit cerebellar cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Associative and non-associative blinking in classically conditioned adult rats.Physiology & behavior · 2009Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The role of the cerebellar cortex in eyeblink classical conditioning remains unclear. Experimental manipulations that disrupt the normal function impair learning to various degrees, and task parameters may be important factors in determining the severity of impairment. This study examined the role of cerebellar cortex in eyeblink conditioning under conditioned stimulus?unconditioned stimulus intervals known to be optimal or nonoptimal for learning. Using infusions of picrotoxin to the interpositus nucleus of the rabbit cerebellum, the authors pharmacologically disrupted input from the cerebellar cortex while training with an interstimulus interval (ISI)-switch procedure. One group of rabbits (Oryctolagus cuniculus) was 1st trained with a 250-ms ISI (optimal) and then switched to a 750-ms ISI (nonoptimal). A 2nd group was trained in the opposite order. The most striking effect was that picrotoxin-treated rabbits initially trained with a 250-ms ISI learned comparably to controls, but those initially trained with a 750-ms ISI were severely impaired. These results suggest that functional input from cerebellar cortex becomes increasingly important for the interpositus nucleus to learn delay eyeblink conditioning as the ISI departs from an optimal interval.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.