ArticleBehavioral neuroscience2009
NMDA receptor involvement in spatial delayed alternation in developing rats.
Article in Behavioral neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 19 citations in OpenAlex.
- Maternal Separation Alters Ethanol Drinking and Reversal Learning Processes in Adolescent Rats: The Impact of Sex and Glycine Transporter Type 1 (GlyT1) Inhibitor.International journal of molecular sciences · 2022Article
- NMDA receptors and the ontogeny of post-shock and retention freezing during contextual fear conditioning.Developmental psychobiology · 2020Article
- Role of miR-34c in the cognitive function of epileptic rats induced by pentylenetetrazol.Molecular medicine reports · 2018Article
- A nonlinear model for hippocampal cognitive prosthesis: memory facilitation by hippocampal ensemble stimulation.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2012Article
- Ontogeny and neural substrates of the context preexposure facilitation effect.Neurobiology of learning and memory · 2011Article
- The H3 antagonist, ciproxifan, alleviates the memory impairment but enhances the motor effects of MK-801 (dizocilpine) in rats.Neuropharmacology · 2010Article
- Medial prefrontal administration of MK-801 impairs T-maze discrimination reversal learning in weanling rats.Behavioural brain research · 2009Article
- Factors governing single-trial contextual fear conditioning in the weanling rat.Behavioral neuroscience · 2009Article
- Spatial discrimination reversal learning in weanling rats is impaired by striatal administration of an NMDA-receptor antagonist.Learning & memory (Cold Spring Harbor, N.Y.) · 2009Article
- Intrahippocampal administration of an NMDA-receptor antagonist impairs spatial discrimination reversal learning in weanling rats.Neurobiology of learning and memory · 2009Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Two experiments examined the effect of the noncompetitive NMDA receptor antagonist, dizocilpine maleate (MK-801), on spatial working memory during development. Rats were trained on spatial delayed alternation (SDA) in a T-maze after ip administration of 0.06 mg/kg MK-801, 0.1 mg/kg MK-801, or saline on postnatal days (P) P23 and P33 (Experiment 1), or following bilateral intrahippocampal administration of 2.5 or 5.0 microg per side MK-801 or saline on P26 (Experiment 2). In Experiment 1, MK-801 dose-dependently impaired SDA learning at both ages. Because the same doses of systemic MK-801 have no effect on T-maze position discrimination learning, impairment of SDA by MK-801 likely reflects disruption of spatial working memory. Both doses of MK-801 abolished acquisition of SDA performance in Experiment 2. Disruption of hippocampal plasticity may account for the effects produced by systemic MK-801 administration. These results confirm and extend earlier lesion studies by implicating plasticity of hippocampal neurons in the ontogeny of spatial delayed alternation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.