ReviewDialogues in clinical neuroscience2008
Toward achieving optimal response: understanding and managing antidepressant side effects.
Review in Dialogues in clinical neuroscience, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers, 10 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
76 citing papers in PubMed, 10 syntheses or guidelines pooled it, 95 citations in OpenAlex.
- A systematic review of the prevalence of fatigue in common mental disorders (mood disorders, anxiety disorders, personality disorders, and trauma and stressor related disorders).BMC psychiatry · 2026Pooled it
- Sexual dysfunction associated with selective serotonin reuptake inhibitors in adults with depression: a systematic review and meta-analysis.European journal of clinical pharmacology · 2026Pooled it
- Individual patient data meta-analysis of placebo-controlled trials of selective serotonin reuptake inhibitors submitted for regulatory approval in adult obsessive-compulsive disorder.The British journal of psychiatry : the journal of mental science · 2025Pooled it
- The use and effect of virtual reality as a non-pharmacological intervention for behavioural and psychological symptoms of dementia: a systematic review and meta-analysis.Age and ageing · 2025Pooled it
- Does physical activity-based intervention decrease repetitive negative thinking? A systematic review.PloS one · 2025Pooled it
- Selective serotonin reuptake inhibitors for premenstrual syndrome and premenstrual dysphoric disorder.The Cochrane database of systematic reviews · 2024Pooled it
- What is the impact of antidepressant side effects on medication adherence among adult patients diagnosed with depressive disorder: A systematic review.Journal of psychopharmacology (Oxford, England) · 2024Pooled it
- Effect of antidepressants on functioning and quality of life outcomes in children and adolescents with major depressive disorder: a systematic review and meta-analysis.Translational psychiatry · 2022Pooled it
- Brexanolone in Postpartum Depression:Journal of women's health (2002) · 2021Pooled it
- The efficacy of psychotherapy, pharmacotherapy and their combination on functioning and quality of life in depression: a meta-analysis.Psychological medicine · 2017Pooled it
- Short-Term and Late-Term Effects of Psilocybin on Symptoms in Major Depression: A Randomized Clinical Trial.JAMA network open · 2026Trial
- A randomized, double-blinded, placebo-controlled study to evaluate the efficacy and safety of venlafaxine extended release in Japanese patients with generalized anxiety disorder.Psychiatry and clinical neurosciences · 2025Trial
- Trial
- Depression education fotonovela for engagement of Hispanic patients in treatment: a randomized clinical trial.BMC psychiatry · 2021Trial
- Efficacy of prospective pharmacogenetic testing in the treatment of major depressive disorder: results of a randomized, double-blind clinical trial.BMC psychiatry · 2017Trial
- Relapse prevention in major depressive disorder: Mindfulness-based cognitive therapy versus an active control condition.Journal of consulting and clinical psychology · 2015Trial
- A randomized controlled longitudinal naturalistic trial testing the effects of automatic self transcending meditation on heart rate variability in late life depression: study protocol.BMC complementary and alternative medicine · 2014Trial
- Safety and tolerability of levomilnacipran ER in major depressive disorder: results from an open-label, 48-week extension study.Clinical drug investigation · 2013Trial
- Preventing relapse in recurrent depression using mindfulness-based cognitive therapy, antidepressant medication or the combination: trial design and protocol of the MOMENT study.BMC psychiatry · 2012Trial
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
16 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The safety and tolerability of antidepressants have improved considerably over the past two decades. Nevertheless, antidepressant side effects are still common and problematic. The majority of patients treated with contemporaty agents experience one or more bothersome side effects. These side effects often create barriers to achieving depressive remission, as well as to preventing relapse and recurrence. Clinicians tend to underestimate the prevalence of side effects, and as many as one quarter of patients discontinue their antidepressants because of difficult-to-tolerate side effects; others may continue on antidepressant therapy but experience diminished quality of life related to troublesome side effects. This article reviews the prevalence of side effects, the impact of side effects on treatment adherence, and methodological issues including the challenge of distinguishing side effects from residual depressive symptoms, discontinuation effects, and general medical problems. In addition, we address the most common side effects such as sexual dysfunction, gastrointestinal problems, sleep disturbance, apathy and fatigue, and offer strategies for management that may help patients achieve optimal response to pharmacotherapy
Indexed as
Identifiers
19170398PMC3181894W1543683634What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.