ArticleThe Prostate2009
Il-1 beta-induced post-transition effect of NF-kappaB provides time-dependent wave of signals for initial phase of intrapostatic inflammation.
Article in The Prostate, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- Anti-Inflammatory Immunoregulatory Effects of Taurocholic Acid Are Mediated by TGR5.Bulletin of experimental biology and medicine · 2026Article
- Unveiling the role of oxidative stress in ANCA-associated glomerulonephritis through integrated machine learning and bioinformatics analyses.Renal failure · 2025Article
- Oxidative Stress in Benign Prostatic Hyperplasia: Mechanisms, Clinical Relevance and Therapeutic Perspectives.Diseases (Basel, Switzerland) · 2025Review
- Article
- Rat astrocytes during anoxia: Secretome profile of cytokines and chemokines.Brain and behavior · 2018Article
- Anti-Inflammatory Effect of Dialyzable Leukocyte Extract in Autoimmune Prostatitis: Evaluation in Animal Model.BioMed research international · 2017Article
- Obesity-initiated metabolic syndrome promotes urinary voiding dysfunction in a mouse model.The Prostate · 2016Article
- Inflammatory Signaling Involved in High-Fat Diet Induced Prostate Diseases.Journal of urology and research · 2015Article
- Effect of modified Zhuye Shigao Decoction and its components on preventing radiation esophagitis of rats.Chinese journal of integrative medicine · 2014Article
- Cytokine effects on cell viability and death of prostate carcinoma cells.BioMed research international · 2014Article
- Role of inflammasomes and their regulators in prostate cancer initiation, progression and metastasis.Cellular & molecular biology letters · 2013Review
- High-fat diet activates pro-inflammatory response in the prostate through association of Stat-3 and NF-κB.The Prostate · 2012Article
- Molecular imaging of nuclear factor-κB in bladder as a primary regulator of inflammatory response.The Journal of urology · 2012Article
- IL-17 Expression by macrophages is associated with proliferative inflammatory atrophy lesions in prostate cancer patients.International journal of clinical and experimental pathology · 2011Article
- Antagonists of growth hormone-releasing hormone (GHRH) reduce prostate size in experimental benign prostatic hyperplasia.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- High-fat diet increases NF-κB signaling in the prostate of reporter mice.The Prostate · 2011Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveOur previous findings have shown that systemic administration of interleukin (IL)-1 beta induces up-regulation of nuclear factor-kappa B (NF-kappaB) in mouse prostate tissue that may be responsible for leukocyte extravasation into prostate stroma. It has been hypothesized that NF-kappaB plays a role in the development of prostatitis, and that NF-kappaB activation might provide chemoattractive signals for leukocyte extravasation in the prostate.
methodsIL-1 beta was administrated intravenously, alone or with dexamethasone (Dex), to separate groups of C57BL/6J mice. Expression of NF-kappaB, chemoattractant receptors, and IL-17F in the prostates of the two groups of mice at various time periods following treatment was evaluated and compared.
resultsIL-1 beta administration up-regulated NF-kappaB/p65 activity in the mouse prostate. IL-1 beta administration promoted extravasation and accumulation of CD45+ mononuclear cells but not neutrophils in the mouse prostate stroma. IL-1 beta administration provided earlier (4 hr) CXCR1/IL-8RA receptor expression in mouse prostate as a first signal, inducing capillary homing, adhesion, and initial extravasation of mononuclear cells into the prostate tissue. IL-1 beta administration also induced relatively late (24 hr) up-regulation of VCAM1 in the endothelial cells of microvessels and of IL-17F in prostate epithelium and in stromal infiltrating leukocytes. Concomitant administration of Dex, a known NF-kappaB inhibitor, resulted in significantly down-regulated IL-1 beta-induced NF-kappaB/p65 activity, as well as reduced expression of chemokine receptors and IL-17F in mouse prostate tissue.
conclusionSystemic IL-1 beta administration induces NF-kappaB-responsive genes to promote aberrant NF-kappaB/p65 activity, which may be critical in the development of prostatitis through its role in the production of chemoattractant signals that promote extravasation and stromal accumulation of mononuclear cells (mainly by CXCR1/IL-8RA), and initiation of a new wave of pro-inflammatory signals favorable to chronic inflammation (mainly by IL-17F).
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