ArticleCommunicative & integrative biology2008
A role for vesicular transport of macromolecules across cell walls in fungal pathogenesis.
Article in Communicative & integrative biology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- Extracellular Vesicles and Bacteriophages: New Directions in Environmental Biocolloid Research.Environmental science & technology · 2023Review
- Comparative electrokinetic properties of extracellular vesicles produced by yeast and bacteria.Colloids and surfaces. B, Biointerfaces · 2023Article
- Comparative Genomics ofJournal of fungi (Basel, Switzerland) · 2023Article
- Extracellularly Released Molecules by the Multidrug-Resistant Fungal Pathogens Belonging to theJournal of fungi (Basel, Switzerland) · 2022Review
- Inhibition of Melanization by Kojic Acid Promotes Cell Wall Disruption of the Human Pathogenic FungusPathogens (Basel, Switzerland) · 2022Article
- Article
- FasterJournal of fungi (Basel, Switzerland) · 2022Article
- Formation and characterization of biofilms formed by salt-tolerant yeast strains in seawater-based growth medium.Applied microbiology and biotechnology · 2021Article
- Human IgM Inhibits the Formation of Titan-Like Cells in Cryptococcus neoformans.Infection and immunity · 2020Article
- Transcriptomic Analysis of Extracellular RNA Governed by the Endocytic Adaptor Protein Cin1 ofFrontiers in cellular and infection microbiology · 2020Article
- Anti-melanogenic effects of extracellular vesicles derived from plant leaves and stems in mouse melanoma cells and human healthy skin.Journal of extracellular vesicles · 2020Article
- Extracellular membrane vesicles in the three domains of life and beyond.FEMS microbiology reviews · 2019Review
- Article
- Unconventional protein secretion in plants: a critical assessment.Protoplasma · 2016Review
- Interaction of Cryptococcus neoformans extracellular vesicles with the cell wall.Eukaryotic cell · 2014Article
- Article
- Characterization of Alternaria infectoria extracellular vesicles.Medical mycology · 2014Article
- The impact of proteomics on the understanding of functions and biogenesis of fungal extracellular vesicles.Journal of proteomics · 2014Review
- The multifaceted roles of metabolic enzymes in the Paracoccidioides species complex.Frontiers in microbiology · 2014Review
- Unravelling secretion in Cryptococcus neoformans: more than one way to skin a cat.Mycopathologia · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In our recent work, we have shown that fungal species from different phyla produce extracellular vesicles. The vesicles are heterogeneous and morphologically similar to mammalian exosomes, with intact bilayered membranes. Proteomic analyses reveal that the vesicles contain a broad array of macromolecules, many of which are associated with fungal virulence. Further, the biological import of the extracellular fungal vesicles is supported by their presence during murine cryptococcosis and the immunoreactivity of convalescent serum from patients with Cryptococcus neoformans or Histoplasma capsulatum vesicle protein extracts.In contrast to most eukaryotic cells, fungi have complex cell walls, that could in theory provide a significant barrier to the secretion of large molecules. The discovery of trans-cell wall vesicular transport in fungi provides a solution to the problem of extracellular transport of macromolecules. Identifying similar vesicles in ascomycetes and basidiomycetes suggest that the shuttle system is ancient, predating the divergence of these branches 0.5-1.0 billion years ago. Importantly, the discovery of this trans-cell wall vesicular transport system also poses new, interesting questions for future investigations.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.