ArticleOncogene2009
Runx3 expression in gastrointestinal tract epithelium: resolving the controversy.
Article in Oncogene, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Association between RUNX3 promoter methylation and gastric cancer: a meta-analysis.BMC gastroenterology · 2011Pooled it
- Gastric Cancer: Pathobiology and Therapeutics.MedComm · 2026Review
- The mechanisms of gastric mucosal injury: focus on initial chief cell loss as a key target.Cell death discovery · 2023Review
- Article
- An inverse relationship between the expression of the gastric tumor suppressor RUNX3 and infection with Helicobacter pylori in gastric epithelial dysplasia.Gut and liver · 2013Article
- RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status.Pathology oncology research : POR · 2012Article
- RUNX3 is expressed in the epithelium of the gastrointestinal tract.EMBO molecular medicine · 2012Article
- Runx1 is a tumor suppressor gene in the mouse gastrointestinal tract.Cancer science · 2012Article
- Article
- Absence of Runx3 expression in normal gastrointestinal epithelium calls into question its tumour suppressor function.EMBO molecular medicine · 2011Article
- Down-regulation of Runx1 expression by TCR signal involves an autoregulatory mechanism and contributes to IL-2 production.The Journal of biological chemistry · 2011Article
- Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer.Oncogene · 2010Article
- Review
- RUNX3 as a Potential Predictor of Metastasis in Human Pancreatic Cancer.In vivo (Athens, Greece)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported earlier that RUNX3 is expressed in human and mouse gastrointestinal tract (GIT) epithelium and that it functions as a tumor suppressor in gastric and colorectal tissues. However, there have been conflicting reports describing the absence of Runx3 in GIT epithelial cells. A part of the controversy may be derived from the use of a specific antibody by other groups (referred to as G-poly). Here, we show further evidence to support our earlier observations and provide a possible explanation for this apparent controversy. We generated multiple anti-RUNX3 monoclonal antibodies and found that RUNX3 antibodies recognizing the RUNX3 N-terminal region (residues 1-234) react with RUNX3 in gastric epithelial cells, whereas those recognizing the C-terminal region (beyond residue 234) did not. G-poly primarily recognizes the region beyond 234 and hence, is unable to detect Runx3 in this tissue.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.