Evidence map›Paper›PMID 19169178›Full record

ReviewAmerican journal of physical medicine & rehabilitation2009

The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology.

Fabrisia Ambrosio, Fawzi Kadi, Jan Lexell, G Kelley Fitzgerald, Michael L Boninger, Johnny Huard

Abstract readReview
In one paragraph

Review in American journal of physical medicine & rehabilitation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Aligned Collagen Sponges Loaded With Myogenic Factors to Enhance Skeletal Muscle Tissue Regeneration.Journal of biomedical materials research. Part B, Applied biomaterials · 2025
    Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Nutrition research and practice · 2022
    Article
  7. Frontiers in nutrition · 2022
    Article
  8. A Coupled Mechanobiological Model of Muscle Regeneration In Cerebral Palsy.Frontiers in bioengineering and biotechnology · 2021
    Article
  9. The regulatory role of melatonin in skeletal muscle.Journal of muscle research and cell motility · 2020
    Review
  10. HIF-1α Directly Controls WNT7A Expression During Myogenesis.Frontiers in cell and developmental biology · 2020
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fabrisia AmbrosioDepartment of Physical Medicine and Rehabilitation, University of Pittsburgh, Pittsburgh, PA 15213, USA.
Fawzi Kadi
Jan Lexell
G Kelley Fitzgerald
Michael L Boninger
Johnny Huard

Funding

VARIABILITY, STABILITY & SMOOTHNESS OF WALKINGP30AG024827 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JENNIFER S BRACH · 2004 to 2026
$28.6M
NIA NIH HHS P30 AG024827PHS HHS K12
6 · The paper itself

Abstract

Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there has been relatively little impact in the clinical approaches used to treat skeletal muscle injuries and wasting. The purpose of this review article is to provide an overview of the basic biology of satellite cell function in response to muscle loading and to relate these findings in the context of aging and neuromuscular pathology for the rehabilitation medicine specialist.

Indexed as

AgingAnimalsCell DifferentiationExerciseHindlimb SuspensionHumansInsulin-Like Growth Factor IMuscle, SkeletalMuscular Dystrophy, DuchenneRegenerationResearchSatellite Cells, Skeletal MuscleInsulin-Like Growth Factor I

Identifiers

PMID19169178
PMCPMC4872620

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.