ArticleInvestigative ophthalmology & visual science2009
Multiple genes on chromosome 7 regulate dopaminergic amacrine cell number in the mouse retina.
Article in Investigative ophthalmology & visual science, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 40 citations in OpenAlex.
- Neurog2 regulates Isl1 to modulate horizontal cell number.Development (Cambridge, England) · 2023Article
- Quantitative trait loci on chromosomes 9 and 19 modulate AII amacrine cell number in the mouse retina.Frontiers in neuroscience · 2023Article
- Interrelationships between Cellular Density, Mosaic Patterning, and Dendritic Coverage of VGluT3 Amacrine Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Inner retinal preservation in the photoinducible I307N rhodopsin mutant mouse, a model of autosomal dominant retinitis pigmentosa.The Journal of comparative neurology · 2020Article
- Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae.The Journal of comparative neurology · 2020Article
- Using BXD mouse strains in vision research: A systems genetics approach.Molecular vision · 2020Review
- Dopaminergic amacrine cell number, plexus density, and dopamine content in the mouse retina: Strain differences and effects of Bax gene disruption.Experimental eye research · 2018Article
- Article
- Genetic Control of Rod Bipolar Cell Number in the Mouse Retina.Frontiers in neuroscience · 2018Article
- Article
- Prox1 Is a Marker for AII Amacrine Cells in the Mouse Retina.Frontiers in neuroanatomy · 2017Article
- Genomic control of neuronal demographics in the retina.Progress in retinal and eye research · 2016Review
- Design principles and developmental mechanisms underlying retinal mosaics.Biological reviews of the Cambridge Philosophical Society · 2015Review
- Alternative splicing of the LIM-homeodomain transcription factor Isl1 in the mouse retina.Molecular and cellular neurosciences · 2015Article
- Programmed cell death of retinal cone bipolar cells is independent of afferent or target control.Developmental biology · 2014Article
- Sox2 regulates cholinergic amacrine cell positioning and dendritic stratification in the retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Independent genomic control of neuronal number across retinal cell types.Developmental cell · 2014Article
- Pituitary tumor-transforming gene 1 regulates the patterning of retinal mosaics.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Rare variants in LRRK1 and Parkinson's disease.Neurogenetics · 2014Article
- Evaluation of the percentage of ganglion cells in the ganglion cell layer of the rodent retina.Molecular vision · 2013Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThe size of neuronal populations is modulated by gene variants that influence cell production and survival, in turn influencing neuronal connectivity, function, and disease risk. The size of the dopaminergic amacrine (DA) cell population is a highly heritable trait exhibiting sixfold variation among inbred strains of mice and is used here to identify genes that modulate the number of DA cells.
methodsThe entire population was counted in retinal wholemounts from 37 genetically defined lines of mice, including six standard inbred strains, 25 recombinant inbred strains (AXB/BXA), reciprocal F1 hybrids, a chromosome (Chr) 7 consomic line, and three additional genetically modified lines.
resultsMuch of this variation was mapped to a broad locus on Chr 7 (Dopaminergic amacrine cell number control, Chr 7 [Dacnc7]). The Dacnc7 locus is flanked by two candidate genes known to modulate the number of other types of retinal neuron-the proapoptotic gene, Bax, and tyrosinase. The Tyr mutation was shown to modulate DA cell number modestly, though in the direction opposite that predicted. In contrast, Bax deficiency increased the population fourfold. Bax expression was significantly greater in the A/J than in the C57BL/6J strain, an effect that may be attributed to an SNP in a p53 consensus binding site known to modulate transcription. Finally, we note a strong candidate situated at the peak of the Dacnc7 locus, Lrrk1, a Parkinson's disease gene exhibiting missense mutations segregating within the AXB/BXA cross.
conclusionsMultiple polymorphic genes on Chr 7 modulate the size of the population of DA cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.