ArticleMolecular human reproduction2009
The effects of luteinizing hormone ablation/replacement versus steroid ablation/replacement on gene expression in the primate corpus luteum.
Article in Molecular human reproduction, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Hormonal regulation of non-cystic fibrosis transmembrane conductance regulator ion channels in the endocervix.F&S science · 2023Article
- Increased 27-hydroxycholesterol production during luteolysis may mediate the progressive decline in progesterone secretion.Molecular human reproduction · 2018Article
- Changes in immune cell distribution and their cytokine/chemokine production during regression of the rhesus macaque corpus luteum.Biology of reproduction · 2017Article
- Corpus luteum as a novel target of weight changes that contribute to impaired female reproductive physiology and function.Systems biology in reproductive medicine · 2016Article
- Knockdown of Progesterone Receptor (PGR) in Macaque Granulosa Cells Disrupts Ovulation and Progesterone Production.Biology of reproduction · 2016Article
- Dynamics of Immune Cell Types Within the Macaque Corpus Luteum During the Menstrual Cycle: Role of Progesterone.Biology of reproduction · 2015Article
- Quantification of dynamic changes to blood volume and vascular flow in the primate corpus luteum during the menstrual cycle.Journal of medical primatology · 2014Article
- Effects of steroid ablation and progestin replacement on the transcriptome of the primate corpus luteum during simulated early pregnancy.Molecular human reproduction · 2014Article
- Endocrine and local control of the primate corpus luteum.Reproductive biology · 2013Review
- Progesterone inhibition of oxytocin signaling in endometrium.Frontiers in neuroscience · 2013Article
- Comparison of endocrine and cellular mechanisms regulating the corpus luteum of primates and ruminants.Animal reproduction · 2012Article
- Alterations in progesterone receptor membrane component 2 (PGRMC2) in the endometrium of macaques afflicted with advanced endometriosis.Molecular human reproduction · 2012Article
- Microarray analysis of the primate luteal transcriptome during chorionic gonadotrophin administration simulating early pregnancy.Molecular human reproduction · 2012Article
- Liver x receptor modulation of gene expression leading to proluteolytic effects in primate luteal cells.Biology of reproduction · 2012Article
- Analysis of microarray data from the macaque corpus luteum; the search for common themes in primate luteal regression.Molecular human reproduction · 2011Review
- Dynamics of the transcriptome in the primate ovulatory follicle.Molecular human reproduction · 2011Article
- The effect of progesterone replacement on gene expression in the corpus luteum during induced regression and late luteal phase in the bonnet monkey (Macaca radiata).Reproductive biology and endocrinology : RB&E · 2011Article
- Effect of decreasing intraluteal progesterone on sensitivity of the early porcine corpus luteum to the luteolytic actions of prostaglandin F2alpha.Biology of reproduction · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
This study was designed to provide a genome-wide analysis of the effects of luteinizing hormone (LH) versus steroid ablation/replacement on gene expression in the developed corpus luteum (CL) in primates during the menstrual cycle. On Days 9-11 of the luteal phase, female rhesus monkeys were left untreated (control) or received a GnRH antagonist Antide (A), A + LH, A + LH + the 3beta-hydroxysteroid dehydrogenase inhibitor Trilostane (TRL) or A + LH + TRL + a progestin R5020. On Day 12 of the luteal phase, CL were removed and samples of RNA from individual CL were hybridized to Affymetrix rhesus macaque total genome microarrays. The greatest number of altered transcripts was associated with the ablation/replacement of LH, while steroid ablation/progestin replacement affected fewer transcripts. Replacement of LH during Antide treatment restored the expression of most transcripts to control levels. Validation of a subset of transcripts revealed that the expression patterns were similar between microarray and real-time PCR. Analyses of protein levels were subsequently determined for two transcripts. This is the first genome-wide analysis of LH and steroid regulation of gene transcription in the developed primate CL. Further analysis of novel transcripts identified in this data set can clarify the relative role for LH and steroids in CL maintenance and luteolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.