ArticleJournal of child neurology2009
Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational age.
Article in Journal of child neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
64 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.
- Effect of neonatal therapy on the motor, cognitive, and behavioral development of infants born preterm: a systematic review.Developmental medicine and child neurology · 2020Pooled it
- Prognostic factors for cerebral palsy and motor impairment in children born very preterm or very low birthweight: a systematic review.Developmental medicine and child neurology · 2016Pooled it
- Association between Term Equivalent Brain Magnetic Resonance Imaging and 2-Year Outcomes in Extremely Preterm Infants: A Report from the Preterm Erythropoietin Neuroprotection Trial Cohort.The Journal of pediatrics · 2021Trial
- Intracranial Hemorrhage and 2-Year Neurodevelopmental Outcomes in Infants Born Extremely Preterm.The Journal of pediatrics · 2021Trial
- Trial
- Antenatal Magnesium and Cerebral Palsy in Preterm Infants.The Journal of pediatrics · 2015Trial
- Optimising nutrition to improve growth and reduce neurodisabilities in neonates at risk of neurological impairment, and children with suspected or confirmed cerebral palsy.BMC pediatrics · 2015Trial
- Trial
- Reader variability in the use of diagnostic terms to describe white matter lesions seen on cranial scans of severely premature infants: the ELGAN study.Journal of clinical ultrasound : JCU · 2010Trial
- Re-evaluating the timing of sequential cranial ultrasound screening in very preterm infants for predicting neurodevelopmental outcomes.Pediatric radiology · 2025Article
- Does tranexamic acid reduce transfusion requirements in children with cerebral palsy undergoing osteotomies? A systematic review and meta-analysis.Journal of orthopaedics · 2024Review
- Life on the Frontlines: Caregiver Experience of Pediatric Cerebrospinal Shunt Malfunction.Pediatric neurology · 2023Article
- Evaluation of Autism Spectrum Disorder Risk in Infants With Intraventricular Hemorrhage.Cureus · 2023Article
- A novel magnetic resonance imaging-based scoring system to predict outcome in neonates born preterm with intraventricular haemorrhage.Developmental medicine and child neurology · 2022Observational
- Association of Abnormal Findings on Neonatal Cranial Ultrasound With Neurobehavior at Neonatal Intensive Care Unit Discharge in Infants Born Before 30 Weeks' Gestation.JAMA network open · 2022Article
- Overview of Perinatal Practices with Potential Neurodevelopmental Impact for Children Affected by Preterm Birth.The Journal of pediatrics · 2022Article
- Extreme prematurity: Risk and resiliency.Current problems in pediatric and adolescent health care · 2022Review
- Placental transcriptional signatures associated with cerebral white matter damage in the neonate.Frontiers in neuroscience · 2022Article
- Neonatal Cranial Ultrasound Findings among Infants Born Extremely Preterm: Associations with Neurodevelopmental Outcomes at 10 Years of Age.The Journal of pediatrics · 2021Article
- Survival of Ventilated Extremely Premature Neonates With Severe Intraventricular Hemorrhage.Pediatrics · 2021Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
22 authors at 14 institutions in 1 country.
Funding
Abstract
Our prospective cohort study of extremely low gestational age newborns evaluated the association of neonatal head ultrasound abnormalities with cerebral palsy at age 2 years. Cranial ultrasounds in 1053 infants were read with respect to intraventricular hemorrhage, ventriculomegaly, and echolucency, by multiple sonologists. Standardized neurological examinations classified cerebral palsy, and functional impairment was assessed. Forty-four percent with ventriculomegaly and 52% with echolucency developed cerebral palsy. Compared with no ultrasound abnormalities, children with echolucency were 24 times more likely to have quadriparesis and 29 times more likely to have hemiparesis. Children with ventriculomegaly were 17 times more likely to have quadriparesis or hemiparesis. Forty-three percent of children with cerebral palsy had normal head ultrasound. Focal white matter damage (echolucency) and diffuse damage (late ventriculomegaly) are associated with a high probability of cerebral palsy, especially quadriparesis. Nearly half the cerebral palsy identified at 2 years is not preceded by a neonatal brain ultrasound abnormality.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.