ArticleApplied and environmental microbiology2009
Exploring the diversity of the bifidobacterial population in the human intestinal tract.
Article in Applied and environmental microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.
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Who cites it
166 citing papers in PubMed.
- Gut microbiome stability and dynamics in healthy donors and patients with non-gastrointestinal cancers.The Journal of experimental medicine · 2021Trial
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- Bifidobacterial succession and correlation networks in a large unselected cohort of mothers and their children.Applied and environmental microbiology · 2013Trial
- Global biogeography ofGut microbes · 2026Review
- Genetic and enzymatic basis of xylooligosaccharide metabolism byGut microbes · 2026Article
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- Whole genome sequence analysis ofJournal of animal science and technology · 2026Article
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- Gut microbiota in regulatory T cell generation and function: mechanisms and health implications.Gut microbes · 2025Review
- Gut microbial production of imidazole propionate drives Parkinson's pathologies.Nature communications · 2025Article
- Quorum Sensing via Autoinducer-2 Promotes Colonisation and Host Adaptation in B. bifidum PRL2010.Microbial biotechnology · 2025Article
- The role of teichoic acids of bifidobacteria in driving the interaction with the human host.Frontiers in microbiology · 2025Article
- Unveiling the neonatal gut microbiota: exploring the influence of delivery mode on early microbial colonization and intervention strategies.Archives of gynecology and obstetrics · 2024Review
- Variation in the Conservation of Species-Specific Gene Sets for HMO Degradation and Its Effects on HMO Utilization in Bifidobacteria.Nutrients · 2024Article
- Probiotics in the New Era of Human Milk Oligosaccharides (HMOs): HMO Utilization and Beneficial Effects ofMicroorganisms · 2024Review
- Genomic Characterization and Safety Assessment ofJournal of microbiology and biotechnology · 2024Article
- Diversity Analysis of Intestinal Bifidobacteria in the Hohhot Population.Microorganisms · 2024Article
- Genetic specialization of key bifidobacterial phylotypes in multiple mother-infant dyad cohorts from geographically isolated populations.Frontiers in microbiology · 2024Article
- Unveiling metabolic pathways of selected plant-derived glycans byFrontiers in microbiology · 2024Article
106 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the health-promoting roles of bifidobacteria are widely accepted, the diversity of bifidobacteria among the human intestinal microbiota is still poorly understood. We performed a census of bifidobacterial populations from human intestinal mucosal and fecal samples by plating them on selective medium, coupled with molecular analysis of selected rRNA gene sequences (16S rRNA gene and internally transcribed spacer [ITS] 16S-23S spacer sequences) of isolated colonies. A total of 900 isolates were collected, of which 704 were shown to belong to bifidobacteria. Analyses showed that the culturable bifidobacterial population from intestinal and fecal samples include six main phylogenetic taxa, i.e., Bifidobacterium longum, Bifidobacterium pseudocatenulatum, Bifidobacterium adolescentis, Bifidobacterium pseudolongum, Bifidobacterium breve, and Bifidobacterium bifidum, and two species mostly detected in fecal samples, i.e., Bifidobacterium dentium and Bifidobacterium animalis subp. lactis. Analysis of bifidobacterial distribution based on age of the subject revealed that certain identified bifidobacterial species were exclusively present in the adult human gut microbiota whereas others were found to be widely distributed. We encountered significant intersubject variability and composition differences between fecal and mucosa-adherent bifidobacterial communities. In contrast, a modest diversification of bifidobacterial populations was noticed between different intestinal regions within the same individual (intrasubject variability). Notably, a small number of bifidobacterial isolates were shown to display a wide ecological distribution, thus suggesting that they possess a broad colonization capacity.
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