ArticleProceedings of the National Academy of Sciences of the United States of America2009
Multiple transcription factor codes activate epidermal wound-response genes in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 59 citations in OpenAlex.
- The Developmental Disorders of Fall Armyworm (Microorganisms · 2025Article
- Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024Review
- Tachykinin-related peptides modulate immune-gene expression in the mealworm beetle Tenebrio molitor L.Scientific reports · 2022Article
- Glial immune-related pathways mediate effects of closed head traumatic brain injury on behavior and lethality in Drosophila.PLoS biology · 2022Article
- Transcriptional and signalling regulation of skin epithelial stem cells in homeostasis, wounds and cancer.Experimental dermatology · 2021Review
- Spotlight on the Granules (Grainyhead-Like Proteins) - From an Evolutionary Conserved Controller of Epithelial Trait to Pioneering the Chromatin Landscape.Frontiers in molecular biosciences · 2020Review
- Requirement for and polarized localization of integrin proteins during Drosophila wound closure.Molecular biology of the cell · 2018Article
- Toll pathway is required for wound-induced expression of barrier repair genes in theProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Stable Binding of the Conserved Transcription Factor Grainy Head to its Target Genes Throughout Drosophila melanogaster Development.Genetics · 2017Article
- Review
- Direct interaction of avermectin with epidermal growth factor receptor mediates the penetration resistance in Drosophila larvae.Open biology · 2016Article
- Interplay among Drosophila transcription factors Ets21c, Fos and Ftz-F1 drives JNK-mediated tumor malignancy.Disease models & mechanisms · 2015Article
- A Comprehensive Transcriptomic and Proteomic Analysis of Hydra Head Regeneration.Molecular biology and evolution · 2015Article
- Rapid clearance of epigenetic protein reporters from wound edge cells inRegeneration (Oxford, England) · 2014Article
- Polyploidization and cell fusion contribute to wound healing in the adult Drosophila epithelium.Current biology : CB · 2013Article
- Microinjection wound assay and in vivo localization of epidermal wound response reporters in Drosophila embryos.Journal of visualized experiments : JoVE · 2013Article
- The role of transcription-independent damage signals in the initiation of epithelial wound healing.Nature reviews. Molecular cell biology · 2013Review
- Serine proteolytic pathway activation reveals an expanded ensemble of wound response genes in Drosophila.PloS one · 2013Article
- Sociogenomics of cooperation and conflict during colony founding in the fire ant Solenopsis invicta.PLoS genetics · 2013Article
- Transcriptional regulation of Profilin during wound closure in Drosophila larvae.Journal of cell science · 2012Article
Corrections and comments
- Erratum issuedDrivenes, Øyvind [added]
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Wounds in Drosophila and mouse embryos induce similar genetic pathways to repair epidermal barriers. However, the transcription factors that transduce wound signals to repair epidermal barriers are largely unknown. We characterize the transcriptional regulatory enhancers of 4 genes-Ddc, ple, msn, and kkv-that are rapidly activated in epidermal cells surrounding wounds in late Drosophila embryos and early larvae. These epidermal wound enhancers all contain evolutionarily conserved sequences matching binding sites for JUN/FOS and GRH transcription factors, but vary widely in trans- and cis-requirements for these inputs and their binding sites. We propose that the combination of GRH and FOS is part of an ancient wound-response pathway still used in vertebrates and invertebrates, but that other mechanisms have evolved that result in similar transcriptional output. A common, but largely untested assumption of bioinformatic analyses of gene regulatory networks is that transcription units activated in the same spatial and temporal patterns will require the same cis-regulatory codes. Our results indicate that this is an overly simplistic view.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.