ArticleJournal of the American Dietetic Association2009
Genetic variants in phosphatidylethanolamine N-methyltransferase and methylenetetrahydrofolate dehydrogenase influence biomarkers of choline metabolism when folate intake is restricted.
Article in Journal of the American Dietetic Association, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Choline and betaine concentrations in plasma discriminate levels of dietary choline intake in healthy adults: analysis of a double-blind randomized crossover controlled feeding study.The American journal of clinical nutrition · 2026Trial
- Depressive Symptoms Associated with Decreased Choline Intake in Lactating Mothers of Preterm Infants.Nutrients · 2026Article
- Contrasting Effects of Phosphatidylcholine and Betaine Supplementation on Embryonic Development in a Mouse Model of the MTHFD1 R653Q Variant.The Journal of nutrition · 2025Article
- Article
- Personalized Nutrition in the Management of Female Infertility: New Insights on Chronic Low-Grade Inflammation.Nutrients · 2022Review
- Study on the correlation between homocysteine-related dietary patterns and gestational diabetes mellitus:a reduced-rank regression analysis study.BMC pregnancy and childbirth · 2022Article
- Mild Choline Deficiency and MTHFD1 Synthetase Deficiency Interact to Increase Incidence of Developmental Delays and Defects in Mice.Nutrients · 2021Article
- Targeting lipid droplet lysophosphatidylcholine for cisplatin chemotherapy.Journal of cellular and molecular medicine · 2020Article
- Independent and Interactive Influences of Environmental UVR, Vitamin D Levels, and Folate VariantNutrients · 2020Article
- Common Genetic Variants Alter Metabolism and Influence Dietary Choline Requirements.Nutrients · 2017Review
- High dietary folate in pregnant mice leads to pseudo-MTHFR deficiency and altered methyl metabolism, with embryonic growth delay and short-term memory impairment in offspring.Human molecular genetics · 2017Article
- Choline metabolites: gene by diet interactions.Current opinion in lipidology · 2016Review
- Evidence for negative selection of gene variants that increase dependence on dietary choline in a Gambian cohort.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Maternal choline concentrations during pregnancy and choline-related genetic variants as risk factors for neural tube defects.The American journal of clinical nutrition · 2014Article
- Geographical and ethnic distribution of single nucleotide polymorphisms within genes of the folate/homocysteine pathway metabolism.Genes & nutrition · 2014Article
- Metabolic crosstalk between choline/1-carbon metabolism and energy homeostasis.Clinical chemistry and laboratory medicine · 2013Review
- Nutrition in pregnancy: the argument for including a source of choline.International journal of women's health · 2013Article
- Reduced MTHFD1 activity in male mice perturbs folate- and choline-dependent one-carbon metabolism as well as transsulfuration.The Journal of nutrition · 2013Article
- Plasma choline metabolites associate with metabolic stress among young overweight men in a genotype-specific manner.Nutrition & diabetes · 2012Article
- The nutrigenetics and nutrigenomics of the dietary requirement for choline.Progress in molecular biology and translational science · 2012Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Choline is a required nutrient with roles in liver and brain function, lipid metabolism, and fetal development. Recent data suggest that choline requirements may be altered by polymorphisms in the phosphatidylethanolamine N-methyltransferase (PEMT) gene (ie, 5465G-->A; rs7946 and -744G-->C; rs12325817) and in the methylenetetrahydrofolate dehydrogenase (MTHFD1) gene (ie, 1958G-->A; rs2236225). This controlled feeding study, conducted in 2000-2001, examined the effects of the PEMT and MTHFD1 genetic variants on biomarkers of choline metabolism in premenopausal Mexican-American women (N=43) after a 7-week period of folate restriction (135 microg as dietary folate equivalents) and after a 7-week period of folate treatment (400 and 800 microg dietary folate equivalents/day combined). Throughout the 14-week study choline intake remained constant at 349 mg/day. The genotype frequencies of the women were 3GG, 19GA, and 21AA for PEMT G5465A; 9GG, 17GC and 17CC for PEMT G-744C; and 9GG, 21GA and 13AA for MTHFD1 G1958A. During folate restriction, homocysteine was adversely influenced by PEMT 5465AA (P=0.001 relative to the G allele) and by MTHFD1 1958AA (P=0.085 relative to 1958GG); whereas the decline in phosphatidylcholine was attenuated by PEMT -744CC (P=0.017 relative to -744GG). During folate treatment, no effects of the genotypes on the response of the measured variables were detected. These data suggest that polymorphisms in genes relevant to choline metabolism modulate parameters of choline status when folate intake is restricted. Additional studies with larger samples sizes are needed to examine the relationship between these genetic variants and varied choline intake in populations with increased demands for choline (eg, pregnant women).
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