ReviewCurrent opinion in cell biology2009
Calling heads from tails: the role of mathematical modeling in understanding cell polarization.
Review in Current opinion in cell biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- Article
- Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils.Journal of cell science · 2015Article
- Cell memory and adaptation in chemotaxis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Feedback mechanisms in a mechanical model of cell polarization.Physical biology · 2014Article
- Independence of symmetry breaking on Bem1-mediated autocatalytic activation of Cdc42.The Journal of cell biology · 2013Article
- Rsr1 focuses Cdc42 activity at hyphal tips and promotes maintenance of hyphal development in Candida albicans.Eukaryotic cell · 2013Article
- Interaction of motility, directional sensing, and polarity modules recreates the behaviors of chemotaxing cells.PLoS computational biology · 2013Article
- Establishment of a robust single axis of cell polarity by coupling multiple positive feedback loops.Nature communications · 2013Article
- PIP3 waves and PTEN dynamics in the emergence of cell polarity.Biophysical journal · 2012Article
- Weakly nonlinear analysis of symmetry breaking in cell polarity models.Physical biology · 2012Article
- Biased excitable networks: how cells direct motion in response to gradients.Current opinion in cell biology · 2012Review
- Blurred line between chemotactic chase and phagocytic consumption: an immunophysical single-cell perspective.Journal of cell science · 2011Review
- A comparison of mathematical models for polarization of single eukaryotic cells in response to guided cues.PLoS computational biology · 2011Review
- Article
- Tools for analyzing cell shape changes during chemotaxis.Integrative biology : quantitative biosciences from nano to macro · 2010Review
- Cytoskeletal dynamics in fission yeast: a review of models for polarization and division.HFSP journal · 2010Article
- A modular positive feedback-based gene amplifier.Journal of biological engineering · 2010Article
- Dual modes of cdc42 recycling fine-tune polarized morphogenesis.Developmental cell · 2009Article
- Article
- Symmetry breaking in the life cycle of the budding yeast.Cold Spring Harbor perspectives in biology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Theorists have long speculated on the mechanisms driving directed and spontaneous cell polarization. Recently, experimentalists have uncovered many of the mechanisms underlying polarization, enabling these models to be directly tested. In the process, they have demonstrated the explanatory and predictive value of these models and, at the same time, uncovered additional complexities not currently explained by them. In this review, we discuss some of main theories regarding cell polarization and highlight how the intersection of mathematical and experimental biology has yielded new insights into these mechanisms in the case of budding yeast and eukaryotic chemotaxis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.