Trial reportThe Journal of pediatrics2009
Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents.
Trial report in The Journal of pediatrics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 94 citations in OpenAlex.
- Nedocromil sodium for chronic asthma in children.The Cochrane database of systematic reviews · 2006Pooled it
- Reduction in mouse allergen exposure is associated with greater lung function growth.The Journal of allergy and clinical immunology · 2020Trial
- Effect of inhaled glucocorticoids in childhood on adult height.The New England journal of medicine · 2012Trial
- Growth of preschool children at high risk for asthma 2 years after discontinuation of fluticasone.The Journal of allergy and clinical immunology · 2011Trial
- The impact of self-identified race on epidemiologic studies of gene expression.Genetic epidemiology · 2011Trial
- Predictors of remitting, periodic, and persistent childhood asthma.The Journal of allergy and clinical immunology · 2010Trial
- Metabolomic signatures of the steroid biosynthesis driving sex differences in clinical asthma subtypes.Research square · 2026Article
- Determinants of lung function across childhood in the Severe Asthma Research Program (SARP) 3.The Journal of allergy and clinical immunology · 2023Article
- Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma.Nature medicine · 2022Article
- Low gestational vitamin D level and childhood asthma are related to impaired lung function in high-risk children.The Journal of allergy and clinical immunology · 2021Article
- Remission of persistent childhood asthma: Early predictors of adult outcomes.The Journal of allergy and clinical immunology · 2019Article
- The transitioning from trials to extended follow-up studies.Clinical trials (London, England) · 2014Article
- Emerging issues in pediatric asthma: gaps in EPR-3 guidelines for infants and children.Current allergy and asthma reports · 2014Review
- The effects of inhaled corticosteroids on growth in children.The open respiratory medicine journal · 2014Article
- Growth abnormalities in children with type 1 diabetes, juvenile chronic arthritis, and asthma.International journal of endocrinology · 2014Review
- Does Use of Inhaled Corticosteroid for Management of Asthma in Children Make Them Shorter Adults?Pediatric allergy, immunology, and pulmonology · 2013Article
- New directions in immunotherapy.Current allergy and asthma reports · 2013Review
- The Childhood Asthma Management Program (CAMP): Contributions to the Understanding of Therapy and the Natural History of Childhood Asthma.Current respiratory care reports · 2012Article
- International consensus on (ICON) pediatric asthma.Allergy · 2012Article
- Lung effects of inhaled corticosteroids in a rhesus monkey model of childhood asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2012Article
Corrections and comments
- Commented on by
Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
objectivesTo determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued. STUDY
designOf the 1041 participants in the Childhood Asthma Management Program randomized clinical trial, 941 (90%) were followed to determine whether 4.3 years of twice-daily budesonide or nedocromil administration (each compared with placebo) affected subsequent asthma outcomes during a 4.8-year posttrial period in which treatment was managed by the participants' physicians.
resultsThe groups treated continuously during the trial with either budesonide or nedocromil did not differ from the group given placebo in terms of lung function, control of asthma, or psychological status at the end of 4.8 years of posttrial follow-up. However, the decreased mean height in the budesonide group relative to the placebo group at the end of the trial (1.1 cm; P = .005) remained statistically significant (0.9 cm; P = .01) after an additional 4.8 years and was more pronounced in girls (1.7 cm; P = .001) than in boys (0.3 cm; P = .49). Participants in all groups used inhaled corticosteroids during 30% of the posttrial period.
conclusionsClinically meaningful improvements in the control of asthma and in airway responsiveness achieved during continuous treatment with inhaled corticosteroids do not persist after continuous treatment is discontinued.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.