ArticleBiophysical journal2009
Phase equilibria in DOPC/DPPC-d62/cholesterol mixtures.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
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Who cites it
63 citing papers in PubMed.
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- Cholesterol in model membranes.Biophysical reviews · 2025Review
- Structure-guided design of partial agonists at an opioid receptor.Nature communications · 2025Article
- Crystallization ofThe journal of physical chemistry. B · 2025Article
- Lipid Rafts in Signalling, Diseases, and Infections: What Can Be Learned from Fluorescence Techniques?Membranes · 2025Review
- Evaluating the impact of the membrane thickness on the function of the intramembrane protease GlpG.Biophysical journal · 2024Article
- Arginine-Rich Cell-Penetrating Peptides Induce Lipid Rearrangements for Their Active Translocation across Laterally Heterogeneous Membranes.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Cholesterol and Lipid Rafts in the Biogenesis of Amyloid-β Protein and Alzheimer's Disease.Annual review of biophysics · 2024Review
- Multispherical shapes of vesicles with intramembrane domains.The European physical journal. E, Soft matter · 2024Article
- OxPAPC stabilizes liquid-ordered domains in biomimetic membranes.Biophysical journal · 2023Article
- Exclusion of Anchor-Matched Peptide Nucleic Acid from Liquid-Ordered Domains by Hybridization with Complementary Flavin-Labeled DNA.ACS omega · 2023Article
- Time-domain proton-detected local-field NMR for molecular structure determination in complex lipid membranes.Magnetic resonance (Gottingen, Germany) · 2023Article
- Charged Lipids Influence Phase Separation in Cell-Sized Liposomes Containing Cholesterol or Ergosterol.Membranes · 2022Article
- An NMR Study on Hydration and Molecular Interaction of Phytantriol-Based Liquid Crystals.Pharmaceutics · 2022Article
- Possible Role of Bent Structure of Methylated Lithocholic Acid on Artificial and Plasma Membranes.Membranes · 2022Article
- Polyene Antibiotics Physical Chemistry and Their Effect on Lipid Membranes; Impacting Biological Processes and Medical Applications.Membranes · 2022Review
- The Two Faces of the Liquid Ordered Phase.The journal of physical chemistry letters · 2022Article
- Rotational decoupling between the hydrophilic and hydrophobic regions in lipid membranes.Biophysical journal · 2022Article
- Multiscale compression-induced restructuring of stacked lipid bilayers: From buckling delamination to molecular packing.PloS one · 2022Article
3 more citing papers are in PubMed but not listed here.
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3 authors.
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Abstract
There is broad interest in the question of fluid-fluid phase coexistence in membranes, in particular, whether evidence for liquid-disordered (l(d))-liquid-ordered (l(o)) two-phase regions or membrane "rafts" can be found in natural membranes. In model membrane systems, such phase behavior is observed, and we have used deuterium nuclear magnetic resonance spectroscopy to map the phase boundaries of ternary mixtures containing 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC), chain-perdeuterated 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC-d(62)), and cholesterol. For both this ternary model system and the binary DPPC-d(62)/cholesterol system, we present clear evidence for l(d)-l(o) two-phase coexistence. We have selected sample compositions to focus on this region of fluid-fluid phase coexistence and to determine its temperature and composition ranges. The deuterium nuclear magnetic resonance spectra for compositions near the l(d)-l(o) phase boundary at high cholesterol concentrations show evidence of exchange broadening or critical fluctuations in composition, similar to that reported by Vist and Davis. There appears to be a line of critical compositions ranging from 48 degrees C for a DOPC/DPPC-d(62)/cholesterol composition of 0:75:25, to approximately -8 degrees C for the composition 57:14:29. At temperatures below this two-phase region, there is a region of three-phase coexistence (l(d)-l(o)-gel). These results are collected and presented in terms of a partial ternary phase diagram that is consistent with previously reported results of Vist and Davis.
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