ArticleBiophysical journal2009
Model development for the viral Kcv potassium channel.
Article in Biophysical journal, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Modular architecture of KEMBO reports · 2025Review
- Binding kinetics of quaternary ammonium ions in Kcv potassium channels.Channels (Austin, Tex.) · 2024Article
- Asymmetric Interplay Between KFrontiers in physiology · 2021Article
- Inferring functional units in ion channel pores via relative entropy.European biophysics journal : EBJ · 2021Article
- A Functional KViruses · 2020Article
- Coupling of a viral KCommunications biology · 2019Article
- All-atom virus simulations.Current opinion in virology · 2018Review
- Exploring the Viral Channel KcvThe Journal of membrane biology · 2018Article
- Extended beta distributions open the access to fast gating in bilayer experiments-assigning the voltage-dependent gating to the selectivity filter.FEBS letters · 2017Article
- Identification of Intrahelical Bifurcated H-Bonds as a New Type of Gate in KJournal of the American Chemical Society · 2017Article
- Potassium ion channels: could they have evolved from viruses?Plant physiology · 2013Review
- The voltage-sensing domain of a phosphatase gates the pore of a potassium channel.The Journal of general physiology · 2013Article
- Tuning the tetraethylammonium sensitivity of potassium channel Kcv by subunit combination.The Journal of general physiology · 2012Article
- Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis.PloS one · 2012Article
- Mechanism of function of viral channel proteins and implications for drug development.International review of cell and molecular biology · 2012Review
- Membrane anchoring and interaction between transmembrane domains are crucial for K+ channel function.The Journal of biological chemistry · 2011Article
- Viral proteins function as ion channels.Biochimica et biophysica acta · 2011Review
- Salt bridges in the miniature viral channel Kcv are important for function.European biophysics journal : EBJ · 2010Article
- Fast and slow gating are inherent properties of the pore module of the K+ channel Kcv.The Journal of general physiology · 2009Article
- Chlorella virus ATCV-1 encodes a functional potassium channel of 82 amino acids.The Biochemical journal · 2009Article
Corrections and comments
- Erratum issued
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A computational model for the open state of the short viral Kcv potassium channel was created and tested based on homology modeling and extensive molecular-dynamics simulation in a membrane environment. Particular attention was paid to the structure of the highly flexible N-terminal region and to the protonation state of membrane-exposed lysine residues. Data from various experimental sources, NMR spectroscopy, and electrophysiology, as well as results from three-dimensional reference interaction site model integral equation theory were taken into account to select the most reasonable model among possible variants. The final model exhibits spontaneous ion transitions across the complete pore, with and without application of an external field. The nonequilibrium transport events could be induced reproducibly without abnormally large driving potential and without the need to place ions artificially at certain key positions along the transition path. The transport mechanism through the filter region corresponds to the classic view of single-file motion, which in our case is coupled to frequent exchange of ions between the innermost filter position and the cavity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.