ArticleCurrent biology : CB2009
Mature Drosophila meiosis I spindles comprise microtubules of mixed polarity.
Article in Current biology : CB, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 22 citations in OpenAlex.
- Microtubules in Arabidopsis pollen tubes are oriented away from the tube apex and are actin-independent at the cortex.bioRxiv : the preprint server for biology · 2026Article
- The cell cycle oscillator and spindle length set the speed of chromosome separation in Drosophila embryos.Current biology : CB · 2025Article
- Cold-induced meiotic nondisjunction inmicroPublication biology · 2025Article
- The cell cycle oscillator and spindle length set the speed of chromosome separation inbioRxiv : the preprint server for biology · 2024Article
- Article
- Spindle assembly and chromosome dynamics during oocyte meiosis.Current opinion in cell biology · 2019Review
- Oocyte Meiotic Spindle Assembly and Function.Current topics in developmental biology · 2016Review
- The kinesin-13 KLP10A motor regulates oocyte spindle length and affects EB1 binding without altering microtubule growth rates.Biology open · 2014Article
- Synergy between multiple microtubule-generating pathways confers robustness to centrosome-driven mitotic spindle formation.Developmental cell · 2014Article
- Control of oocyte growth and meiotic maturation in Caenorhabditis elegans.Advances in experimental medicine and biology · 2013Review
- Microtubule-depolymerizing kinesin KLP10A restricts the length of the acentrosomal meiotic spindle in Drosophila females.Genetics · 2012Article
- Altered nucleotide-microtubule coupling and increased mechanical output by a kinesin mutant.PloS one · 2012Article
- 50 ways to build a spindle: the complexity of microtubule generation during mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2011Article
- Anastral spindle assembly and γ-tubulin in Drosophila oocytes.BMC cell biology · 2011Article
- HURP permits MTOC sorting for robust meiotic spindle bipolarity, similar to extra centrosome clustering in cancer cells.The Journal of cell biology · 2010Article
- The elegans of spindle assembly.Cellular and molecular life sciences : CMLS · 2010Review
- Anastral spindle assembly: a mathematical model.Biophysical journal · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
New information has been obtained recently regarding microtubule organization in Xenopus extract spindles. These spindles assemble in vitro by chromatin-mediated microtubule nucleation and consist of randomly interspersed long and short microtubules with minus ends distributed throughout the spindle. Fluorescence speckle microscopy has led to the proposal that the Xenopus steady-state spindles contain two overlapping arrays of parallel or antiparallel microtubules with differing poleward-flux velocities. Although some of these features have also been reported for C. elegans female meiotic spindles, it is not clear whether they are representative of microtubule organization and dynamics in oocyte meiotic spindles. Here we examine anastral meiosis I spindles of live Drosophila oocytes expressing the microtubule plus end-tracking protein, EB1, fused to GFP, and find fluorescent particles throughout the spindle and movement toward both the poles and the equator. EB1 particle velocities, corresponding to microtubule growth rates, are similar in both directions, but slower than growth from the poles in mitotic spindles of early embryos. Meiosis I spindles yielded data from photobleaching analysis showing similar microtubule growth rates and dynamics at the poles and the equator, consistent with spindle microtubules of mixed polarity, differing from early-embryo mitotic spindles.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.