ArticleJournal of neurochemistry2009
Phosphatidylinositol 3 kinase-Akt signaling serves as a circadian output in the retina.
Article in Journal of neurochemistry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 40 citations in OpenAlex.
- CCorGsDB: a database for clock correlated genes in the mouse and human central nervous systems.Npj biological timing and sleep · 2026Article
- LPS-aggravated Ferroptosis via Disrupting Circadian Rhythm by Bmal1/AKT/p53 in Sepsis-Induced Myocardial Injury.Inflammation · 2023Article
- Comparative analysis of the daily brain transcriptomes of Asian particolored bat.Scientific reports · 2022Article
- The light response in chickens divergently selected for feather pecking behavior reveals mechanistic insights towards psychiatric disorders.Molecular biology reports · 2022Article
- Translating around the clock: Multi-level regulation of post-transcriptional processes by the circadian clock.Cellular signalling · 2021Review
- The Effect of General Anaesthesia on Circadian Rhythms in Behaviour and Clock Gene Expression ofClocks & sleep · 2020Article
- Circadian regulation in the retina: From molecules to network.The European journal of neuroscience · 2020Review
- Time-of-Day Dependent Neuronal Injury After Ischemic Stroke: Implication of Circadian Clock Transcriptional Factor Bmal1 and Survival Kinase AKT.Molecular neurobiology · 2018Article
- The Contribution of L-Type CaFrontiers in molecular neuroscience · 2017Article
- Circadian Influence on Metabolism and Inflammation in Atherosclerosis.Circulation research · 2016Review
- Cone Viability Is Affected by Disruption of Melatonin Receptors Signaling.Investigative ophthalmology & visual science · 2016Article
- A new role for AMP-activated protein kinase in the circadian regulation of L-type voltage-gated calcium channels in late-stage embryonic retinal photoreceptors.Journal of neurochemistry · 2015Article
- High-Fat Diet-Induced Retinal Dysfunction.Investigative ophthalmology & visual science · 2015Article
- Epigenetic control and the circadian clock: linking metabolism to neuronal responses.Neuroscience · 2014Review
- Chicken embryos as a potential new model for early onset type I diabetes.Journal of diabetes research · 2014Article
- Circadian phase-dependent effect of nitric oxide on L-type voltage-gated calcium channels in avian cone photoreceptors.Journal of neurochemistry · 2013Article
- Two structural components in CNGA3 support regulation of cone CNG channels by phosphoinositides.The Journal of general physiology · 2013Article
- Article
- The circadian clock coordinates ribosome biogenesis.PLoS biology · 2013Article
- Increased superoxide and endothelial NO synthase uncoupling in blood vessels of Bmal1-knockout mice.Circulation research · 2012Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The daily rhythm of L-type voltage-gated calcium channels (L-VGCCs) is part of the cellular mechanism underlying the circadian regulation of retina physiology and function. However, it is not completely understood how the circadian clock regulates L-VGCC current amplitudes without affecting channel gating properties. The phosphatidylinositol 3 kinase-protein kinase B (PI3K-Akt) signaling pathway has been implicated in many vital cellular functions especially in trophic factor-induced ion channel trafficking and membrane insertion. Here, we report that PI3K-Akt signaling participates in the circadian phase-dependent modulation of L-VGCCs. We found that there was a circadian regulation of Akt phosphorylation on Thr308 that peaked at night. Inhibition of PI3K or Akt significantly decreased L-VGCC current amplitudes and the expression of membrane-bound L-VGCCalpha1D subunit only at night but not during the subjective day. Photoreceptors transfected with a dominant negative Ras had significantly less expression of phosphorylated Akt and L-VGCCalpha1D subunit compared with non-transfected photoreceptors. Interestingly, both PI3K-Akt and extracellular signal-related kinase were downstream of Ras, and they appeared to be parallel and equally important pathways to regulate L-VGCC rhythms. Inhibition of either pathway abolished the L-VGCC rhythm indicating that there were multiple mechanisms involved in the circadian regulation of L-VGCC rhythms in retina photoreceptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.