ReviewCritical reviews in immunology2008
Response of gammadelta T Cells to plant-derived tannins.
Review in Critical reviews in immunology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 53 citations in OpenAlex.
- Oral delivery of oligomeric procyanidins in Apple Poly® enhances type I IFN responses in vivo.Journal of leukocyte biology · 2014Trial
- Untargeted metabolomics approach to discriminate mistletoe commercial products.Scientific reports · 2021Article
- Article
- Effect of supplementation of pelleted hazel (Corylus avellana) leaves on blood antioxidant activity, cellular immune response, and heart beat parameters in sheep1.Journal of animal science · 2019Article
- Signatures of selection for resistance to Haemonchus contortus in sheep and goats.BMC genomics · 2019Article
- Therapeutic Potential of Polyphenols from Epilobium Angustifolium (Fireweed).Phytotherapy research : PTR · 2016Review
- Effects of Tannic Acid on the Ischemic Brain Tissue of Rats.Inflammation · 2015Article
- Aging influences the response of T cells to stimulation by the ellagitannin, oenothein B.International immunopharmacology · 2015Article
- Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition.JPEN. Journal of parenteral and enteral nutrition · 2014Article
- Defining the nature of human γδ T cells: a biographical sketch of the highly empathetic.Cellular & molecular immunology · 2013Review
- Characterization of immune modulating functions of γδ T cell subsets in a gnotobiotic pig model of human rotavirus infection.Comparative immunology, microbiology and infectious diseases · 2012Article
- Oenothein B, a cyclic dimeric ellagitannin isolated from Epilobium angustifolium, enhances IFNγ production by lymphocytes.PloS one · 2012Article
- Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression.Journal of leukocyte biology · 2011Article
- Contribution of transcript stability to a conserved procyanidin-induced cytokine response in γδ T cells.Genes and immunity · 2011Article
- Oligomeric procyanidins stimulate innate antiviral immunity in dengue virus infected human PBMCs.Antiviral research · 2011Article
- Article
- Polysaccharides derived from Yamoa (Funtumia elastica) prime gammadelta T cells in vitro and enhance innate immune responses in vivo.International immunopharmacology · 2009Article
- The distinct response of gammadelta T cells to the Nod2 agonist muramyl dipeptide.Cellular immunology · 2009Article
- Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition.JPEN. Journal of parenteral and enteral nutritionArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Many pharmaceutical drugs arc isolated from plants used in traditional medicines, and new plant-derived pharmaceutical drugs continue to be identified. Relevant to this review, different plant-derived agonists for gammadelta T cells are described that impart effector functions upon distinct subsets of these cells. Recently, plant tannins have been defined as one class of gammadelta T cell agonist and appear to preferentially activate the mucosal population. Mucosal gammadelta T cells function to modulate tissue immune responses and induce epithelium repair. Select tannins, isolated from apple peel, rapidly induce immune gene transcription in gammadelta T cells, leading to cytokinc production and increased responsiveness to secondary signals. Activity of these tannin preparations tracks to the procyanidin fraction, with the procyanidin trimer (C1) having the most robust activity defined to date. The response to the procyanidins is evolutionarily conserved in that responses are seen with human, bovine, and murine gammadelta T cells, although human cells show less selectivity. Procyanidin-induced responses described in this review likely account for the expansion of mucosal gammadelta T cells seen in mice and rats fed soluble extracts of tannins. Use of procyanidins to activate gammadelta T cells may represent a novel approach for the treatment of tissue damage and autoimmune diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.