ArticleThe Journal of pathology2009
Older individuals appear to acquire mitotically older colorectal cancers.
Article in The Journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Using tumour phylogenetics to identify the roots of metastasis in humans.Nature reviews. Clinical oncology · 2015Review
- Ancestral inference in tumors: how much can we know?Journal of theoretical biology · 2014Article
- Direct measurements of human colon crypt stem cell niche genetic fidelity: the role of chance in non-darwinian mutation selection.Frontiers in oncology · 2013Review
- Lineage tracing reveals multipotent stem cells maintain human adenomas and the pattern of clonal expansion in tumor evolution.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Modeling evolutionary dynamics of epigenetic mutations in hierarchically organized tumors.PLoS computational biology · 2011Article
- Identification and functional relevance of de novo DNA methylation in cancerous B-cell populations.Journal of cellular biochemistry · 2010Article
- Stress and stem cells.Wiley interdisciplinary reviews. Developmental biologyArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The incidence of many common cancers increases with ageing. The purpose of this study is to infer whether cancer mitotic ages (total numbers of divisions since the zygote) also increase with chronological age. Mitotic ages may be inferred by counting numbers of replication errors or neutral passenger changes. Methylation at certain CpG-rich sequences or 'tags' appears to be proportional to mitotic age, because age-related increases in tag methylation are observed in mitotic tissues such as the colon. Such passenger tag methylation was measured by bisulphite sequencing from 16 colorectal cancers from differently aged male individuals. Both normal colon and cancers exhibited significant age-related increases in tag methylation, but cancer methylation was significantly higher. Therefore, older individuals appear to have mitotically older colorectal cancers. Cell division per se may be an important mechanism underlying the increased incidence of colorectal cancer with ageing, because the neoplastic phase appears more commonly to start from mitotically older crypt stem cells.
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Registered trials
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