ArticleMolecular biology reports2009
Silencing of PMT expression caused a surge of anatabine accumulation in tobacco.
Article in Molecular biology reports, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Metabolic engineering for tobacco quality improvement: Advances and perspectives.Metabolic engineering communications · 2026Review
- Article
- Genetic regulation and manipulation of nicotine biosynthesis in tobacco: strategies to eliminate addictive alkaloids.Journal of experimental botany · 2024Review
- Comparative transcriptome analysis reveals nicotine metabolism is a critical component for enhancing stress response intensity of innate immunity system in tobacco.Frontiers in plant science · 2024Article
- An improved Nicotiana benthamiana bioproduction chassis provides novel insights into nicotine biosynthesis.The New phytologist · 2023Article
- Suppression of pyrrolidine ring biosynthesis and its effects on gene expression and subsequent accumulation of anatabine in leaves of tobacco (N. tabacum L.).BMC genomics · 2023Article
- Nicotine-free, nontransgenic tobacco (Nicotiana tabacum l.) edited by CRISPR-Cas9.Plant biotechnology journal · 2019Article
- Article
- Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drastic increase of anatabine levels was observed in tobacco plants with markedly reduced nicotine concentrations through RNA silencing approaches. By down-regulation of PMT through three kinds of RNA silencing approaches, the nicotine levels decreased accordingly. In lines with slight and moderate reduction of nicotine levels, no anticipated negative linear correlation was found between anatabine and nicotine content. In lines with nicotine levels lower than 2.7 mg/g, drastic elevation of anatabine levels was found. Transcriptional levels of QPRT were unaffected in tobacco lines with surged anatabine levels. This report of an intriguing mutual relationship of nicotine and anatabine sheds new light on mechanisms between metabolic regulations in plants, and reconfirms complexity of metabolic networks.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.