ArticleEuropean archives of psychiatry and clinical neuroscience2009
Exploratory eye movement dysfunction as a discriminator for schizophrenia : a large sample study using a newly developed digital computerized system.
Article in European archives of psychiatry and clinical neuroscience, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The diagnostic role of exploratory eye movement in schizophrenia: a systematic review and meta-analysis.BMC psychiatry · 2025Pooled it
- Exploratory eye movement characteristics to aid screening of schizophrenia and bipolar disorder: A cross-sectional outpatient study.Scientific reports · 2026Article
- The relationship between heart rate variability and eye movement characteristics in adolescents with internet gaming disorder: the mediating role of impulsivity.Frontiers in psychiatry · 2026Article
- Tablet-Based Cognitive and Eye Movement Measures as Accessible Tools for Schizophrenia Assessment: Multisite Usability Study.JMIR mental health · 2024Article
- Exploring the impact of biological alterations in the superior thalamic radiations on exploratory eye movements in attenuated psychosis syndrome.Frontiers in psychiatry · 2024Article
- Trends in big data analyses by multicenter collaborative translational research in psychiatry.Psychiatry and clinical neurosciences · 2022Review
- The development and clinical application of a novel schizophrenia screening system using yoga-induced autonomic nervous system responses.Frontiers in physiology · 2022Article
- Eye movement characteristics in male patients with deficit and non-deficit schizophrenia and their relationships with psychiatric symptoms and cognitive function.BMC neuroscience · 2021Article
- Comparison of resting-state spontaneous brain activity between treatment-naive schizophrenia and obsessive-compulsive disorder.BMC psychiatry · 2021Article
- Recent updates of eye movement abnormalities in patients with schizophrenia: A scoping review.Psychiatry and clinical neurosciences · 2021Article
- Towards Clinically Relevant Oculomotor Biomarkers in Early Schizophrenia.Frontiers in behavioral neuroscience · 2021Article
- Eye movement characteristics in schizophrenia: A recent update with clinical implications.Neuropsychopharmacology reports · 2020Review
- Extraction of Emotional Information via Visual Scanning Patterns: A Feasibility Study of Participants with Schizophrenia and Neurotypical Individuals.ACM transactions on accessible computing · 2018Article
- Manual Dexterity in Schizophrenia-A Neglected Clinical Marker?Frontiers in psychiatry · 2017Article
- Association of chromosome 5q21.3 polymorphisms with the exploratory eye movement dysfunction in schizophrenia.Scientific reports · 2015Article
- Impaired top-down modulation of saccadic latencies in patients with schizophrenia but not in first-degree relatives.Frontiers in behavioral neuroscience · 2015Article
- Eye Movement in Unipolar and Bipolar Depression: A Systematic Review of the Literature.Frontiers in psychology · 2015Review
- Eye-head coordination abnormalities in schizophrenia.PloS one · 2013Article
- Do we have any solid evidence of clinical utility about the pathophysiology of schizophrenia?World psychiatry : official journal of the World Psychiatric Association (WPA) · 2011Article
- Neuroanatomical circuitry associated with exploratory eye movement in schizophrenia: a voxel-based morphometric study.PloS one · 2011Article
Corrections and comments
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Authors and funding
20 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In our previous studies, we identified that exploratory eye movement (EEM) dysfunction appears to be specific to schizophrenia. The availability of a biological marker specific to schizophrenia would be useful for clinical diagnosis of schizophrenia. Consequently, we performed the discriminant analysis between schizophrenics and non-schizophrenics on a large sample using the EEM test data and examined an application of the EEM for clinical diagnosis of schizophrenia. EEM performances were recorded in 251 schizophrenics and 389 non-schizophrenics (111 patients with mood disorders, 28 patients with neurotic disorders and 250 normal controls). The patients were recruited from eight university hospitals and three affiliated hospitals. For this study with a large sample, we developed a new digital computerized version of the EEM test, which automatically handled large amounts of data. We measured four parameters: number of eye fixations (NEF), total eye scanning length (TESL), mean eye scanning length (MESL) and responsive search score (RSS). These parameters of schizophrenics differed significantly from those of the other three groups. The stepwise regression analysis selected the TESL and the RSS as the valid parameters for discriminating between schizophrenics and non-schizophrenics. In the discriminant analysis using the RSS and TESL as prediction parameters, 184 of the 251 clinically diagnosed schizophrenics were discriminated as having schizophrenia (sensitivity 73.3%); and 308 of the 389 clinically diagnosed non-schizophrenic subjects were discriminated as non-schizophrenics (specificity 79.2%). Based on our findings we believe that the EEM measures may be useful for the clinical diagnosis of schizophrenia.
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