ArticleEnvironmental health perspectives2009
Long-term effects on hypothalamic neuropeptides after developmental exposure to chlorpyrifos in mice.
Article in Environmental health perspectives, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 64 citations in OpenAlex.
- Suppression of haptoglobin and loss of striatal neurons in mice chronically exposed to chlorpyrifos-contaminated drinking water.Toxicological sciences : an official journal of the Society of Toxicology · 2026Article
- Egalitarian cooperation linked to central oxytocin levels in communal breeding house mice.Communications biology · 2024Article
- Exploring Astrocytes Involvement and Glutamate Induced Neuroinflammation in Chlorpyrifos-Induced Paradigm Of Autism Spectrum Disorders (ASD).Neurochemical research · 2024Article
- Investigating the prevalence of erectile dysfunction among men exposed to organophosphate insecticides.Journal of endocrinological investigation · 2024Article
- Effects of endocrine-disrupting chemicals on hypothalamic oxytocin and vasopressin systems.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Article
- Prenatal exposure to organophosphate and pyrethroid insecticides and the herbicide 2,4-dichlorophenoxyacetic acid and size at birth in urban pregnant women.Environmental research · 2021Article
- Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos.Behavioral and brain functions : BBF · 2019Article
- Prenatal chlorpyrifos leads to autism-like deficits in C57Bl6/J mice.Environmental health : a global access science source · 2017Article
- Endocrine Disruption of Vasopressin Systems and Related Behaviors.Frontiers in endocrinology · 2017Review
- Adverse Associations of both Prenatal and Postnatal Exposure to Organophosphorous Pesticides with Infant Neurodevelopment in an Agricultural Area of Jiangsu Province, China.Environmental health perspectives · 2016Article
- Prenatal exposure to the organophosphate insecticide chlorpyrifos enhances brain oxidative stress and prostaglandin E2 synthesis in a mouse model of idiopathic autism.Journal of neuroinflammation · 2016Article
- EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals.Endocrine reviews · 2015Review
- Effects of maternal chlorpyrifos diet on social investigation and brain neuroendocrine markers in the offspring - a mouse study.Environmental health : a global access science source · 2015Article
- Protective effects of caffeic acid against hypothalamic neuropeptides alterations induced by malathion in rat.Environmental science and pollution research international · 2015Article
- Prenatal exposure to a common organophosphate insecticide delays motor development in a mouse model of idiopathic autism.PloS one · 2015Article
- Current concepts in neuroendocrine disruption.General and comparative endocrinology · 2014Review
- Chlorpyrifos and neurodevelopmental effects: a literature review and expert elicitation on research and policy.Environmental health : a global access science source · 2012Review
- Endocrine disrupters: a review of some sources, effects, and mechanisms of actions on behaviour and neuroendocrine systems.Journal of neuroendocrinology · 2012Review
- Gestational exposure to the organophosphate chlorpyrifos alters social-emotional behaviour and impairs responsiveness to the serotonin transporter inhibitor fluvoxamine in mice.Psychopharmacology · 2010Article
- Prenatal chlorpyrifos exposure alters motor behavior and ultrasonic vocalization in CD-1 mouse pups.Environmental health : a global access science source · 2009Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIncreasing evidence from animal and human studies indicates that chlorpyrifos (CPF), similar to other organophosphorus insecticides still widely used, is a developmental neurotoxicant. Developmental exposure to CPF in rodents induces sex-dimorphic behavioral changes at adulthood, including social and agonistic responses, which suggests that CPF may interfere with maturation of neuroendocrine mechanisms.
objectivesWe assessed the hypothesis that CPF affects the levels of neurohypophyseal hormones acting as modulators of social behavior in mammals, such as oxytocin (OT), arginine vasopressin (AVP), and prolactin (PRL).
methodsPregnant female mice were orally administered with either vehicle (peanut oil) or 3 or 6 mg/kg CPF on gestational day (GD) 15 to GD18, and offspring were treated subcutaneously with either vehicle or 1 or 3 mg/kg CPF on postnatal days (PNDs) 11 to PND14. Dose levels were chosen to avoid systemic toxicity and inhibition of brain acetylcholinesterase. Offspring were sacrificed at 5 months of age, and expression of OT, AVP, and PRL was analyzed in the hypothalamus by Western blot or enzyme-linked immunosorbent assay (ELISA) analysis.
resultsBoth male and female mice showed dose-related enhancement of OT expression, with males presenting the more intense effect. AVP expression was significantly reduced in male mice at the higher prenatal and postnatal dose. We observed no significant effect on PRL expression in either sex. Overall, outcomes were mainly attributable to fetal exposure, whereas postnatal doses appeared to potentiate the prenatal effects.
conclusionsOur data indicate that developmental exposure to CPF may permanently interfere with specific key signaling proteins of the hypothalamic peptidergic system, with time-, dose-, and sex-related effects still evident at adulthood.
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