ArticlePloS one2009
Nuclear envelope remnants: fluid membranes enriched in sterols and polyphosphoinositides.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 45 citations in OpenAlex.
- Nuclear deformability increases PARPi sensitivity in BRCA1-deficient cells by increasing microtubule-dependent DNA break mobility.Nature communications · 2025Article
- The ESCRT-III isoforms CHMP2A and CHMP2B display different effects on membranes upon polymerization.BMC biology · 2021Article
- DNA damage causes rapid accumulation of phosphoinositides for ATR signaling.Nature communications · 2017Article
- Histones cause aggregation and fusion of lipid vesicles containing phosphatidylinositol-4-phosphate.Biophysical journal · 2015Article
- Effect of polyelectrolyte adsorption on lateral distribution and dynamics of anionic lipids: a Monte Carlo study of a coarse-grain model.European biophysics journal : EBJ · 2014Article
- Histones and DNA compete for binding polyphosphoinositides in bilayers.Biophysical journal · 2014Article
- Clinical and structural features of sperm head vacuoles in men included in the in vitro fertilization programme.BioMed research international · 2014Article
- Phosphoinositides: tiny lipids with giant impact on cell regulation.Physiological reviews · 2013Review
- MARCKS protein is phosphorylated and regulates calcium mobilization during human acrosomal exocytosis.PloS one · 2013Article
- The nuclear membrane as a lipid 'sink'-linking cell cycle progression to lipid synthesis.Journal of chemical biology · 2012Article
- Dynamics of PLCγ and Src family kinase 1 interactions during nuclear envelope formation revealed by FRET-FLIM.PloS one · 2012Article
- A role for phosphoinositides in regulating plant nuclear functions.Frontiers in plant science · 2012Article
- The intrinsically disordered nuclear localization signal and phosphorylation segments distinguish the membrane affinity of two cytidylyltransferase isoforms.The Journal of biological chemistry · 2011Article
- Key role of polyphosphoinositides in dynamics of fusogenic nuclear membrane vesicles.PloS one · 2011Article
- Spatial regulation of membrane fusion controlled by modification of phosphoinositides.PloS one · 2010Article
- Phosphoinositide phosphatases in cell biology and disease.Progress in lipid research · 2010Review
- Nuclear phosphoinositides: a signaling enigma wrapped in a compartmental conundrum.Trends in cell biology · 2010Review
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundThe cytoplasm of eukaryotic cells is a highly dynamic compartment where membranes readily undergo fission and fusion to reorganize the cytoplasmic architecture, and to import, export and transport various cargos within the cell. The double membrane of the nuclear envelope that surrounds the nucleus, segregates the chromosomes from cytoplasm and regulates nucleocytoplasmic transport through pores. Many details of its formation are still unclear. At fertilization the sperm devoid of nuclear envelope pores enters the egg. Although most of the sperm nuclear envelope disassembles, remnants of the envelope at the acrosomal and centriolar fossae do not and are subsequently incorporated into the newly forming male pronuclear envelope. Remnants are conserved from annelid to mammalian sperm. METHODOLOGY/PRINCIPAL
findingsUsing lipid mass spectrometry and a new application of deuterium solid-state NMR spectroscopy we have characterized the lipid composition and membrane dynamics of the sperm nuclear envelope remnants in isolated sperm nuclei. CONCLUSIONS/SIGNIFICANCE: We report nuclear envelope remnants are relatively fluid membranes rich in sterols, devoid of sphingomyelin, and highly enriched in polyphosphoinositides and polyunsaturated phospholipids. The localization of the polybasic effector domain of MARCKS illustrates the non-nuclear aspect of the polyphosphoinositides. Based on their atypical biophysical characteristics and phospholipid composition, we suggest a possible role for nuclear envelope remnants in membrane fusion leading to nuclear envelope assembly.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.