ArticlePLoS genetics2009
Multiple chromosomal rearrangements structured the ancestral vertebrate Hox-bearing protochromosomes.
Article in PLoS genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 21 citations in OpenAlex.
- Ancient nuclear genome duplication events in vertebrates facilitated the functional diversification of ohnologous cytochrome c: insights from Buergeria frogs.Molecular biology and evolution · 2026Article
- Phylogenomics reveals an almost perfect polytomy among the almost ungulates (bioRxiv : the preprint server for biology · 2023Article
- Why Do Some Vertebrates Have Microchromosomes?Cells · 2021Review
- Deeply conserved synteny resolves early events in vertebrate evolution.Nature ecology & evolution · 2020Article
- Review
- Chromosome evolution at the origin of the ancestral vertebrate genome.Genome biology · 2018Article
- Non-parsimonious evolution of hagfish Dlx genes.BMC evolutionary biology · 2013Article
- Mechanisms of Gene Duplication and Translocation and Progress towards Understanding Their Relative Contributions to Animal Genome Evolution.International journal of evolutionary biology · 2012Article
- Identification of distant Agouti-like sequences and re-evaluation of the evolutionary history of the Agouti-related peptide (AgRP).PloS one · 2012Article
- Hox gene clusters of early vertebrates: do they serve as reliable markers for genome evolution?Genomics, proteomics & bioinformatics · 2011Review
- Silencing, positive selection and parallel evolution: busy history of primate cytochromes C.PloS one · 2011Article
- Evolution of developmental regulation in the vertebrate FgfD subfamily.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2010Article
- Elephant shark (Callorhinchus milii) provides insights into the evolution of Hox gene clusters in gnathostomes.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Consequences of lineage-specific gene loss on functional evolution of surviving paralogs: ALDH1A and retinoic acid signaling in vertebrate genomes.PLoS genetics · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While the proposal that large-scale genome expansions occurred early in vertebrate evolution is widely accepted, the exact mechanisms of the expansion--such as a single or multiple rounds of whole genome duplication, bloc chromosome duplications, large-scale individual gene duplications, or some combination of these--is unclear. Gene families with a single invertebrate member but four vertebrate members, such as the Hox clusters, provided early support for Ohno's hypothesis that two rounds of genome duplication (the 2R-model) occurred in the stem lineage of extant vertebrates. However, despite extensive study, the duplication history of the Hox clusters has remained unclear, calling into question its usefulness in resolving the role of large-scale gene or genome duplications in early vertebrates. Here, we present a phylogenetic analysis of the vertebrate Hox clusters and several linked genes (the Hox "paralogon") and show that different phylogenies are obtained for Dlx and Col genes than for Hox and ErbB genes. We show that these results are robust to errors in phylogenetic inference and suggest that these competing phylogenies can be resolved if two chromosomal crossover events occurred in the ancestral vertebrate. These results resolve conflicting data on the order of Hox gene duplications and the role of genome duplication in vertebrate evolution and suggest that a period of genome reorganization occurred after genome duplications in early vertebrates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.