ArticlePloS one2009
Ca extrusion by NCX is compromised in olfactory sensory neurons of OMP mice.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 60 citations in OpenAlex.
- Evolutionary trajectories of teleost olfactory signaling genes shaped by long-term redundancy after whole-genome duplication.iScience · 2026Article
- The effects of voltage dependence and ion-binding reaction rates on a thermodynamically constrained mathematical model of the Na/Ca exchanger.Scientific reports · 2025Article
- Olfactory marker protein contains a leucine-rich domain in the Ω-loop important for nuclear export.Molecular brain · 2022Article
- Olfactory marker protein interacts with adenosine nucleotide derivatives.Biochemistry and biophysics reports · 2021Article
- The functional relevance of olfactory marker protein in the vertebrate olfactory system: a never-ending story.Cell and tissue research · 2021Review
- Immunocytochemical Localization of Olfactory-signaling Molecules in Human and Rat Spermatozoa.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Olfactory marker protein directly buffers cAMP to avoid depolarization-induced silencing of olfactory receptor neurons.Nature communications · 2020Article
- Differential Expression of Mucins in Murine Olfactory Versus Respiratory Epithelium.Chemical senses · 2019Article
- Olfactory receptor neurons express olfactory marker protein but not calpain 5 from the same genomic locus.Molecular brain · 2019Article
- Article
- Olfactory Receptor OR51E1 Mediates GLP-1 Secretion in Human and Rodent Enteroendocrine L Cells.Journal of the Endocrine Society · 2018Article
- Olfactory marker protein regulates prolactin secretion and production by modulating CaExperimental & molecular medicine · 2018Article
- Differential spatial expression of peripheral olfactory neuron-derived BACE1 induces olfactory impairment by region-specific accumulation of β-amyloid oligomer.Cell death & disease · 2017Article
- Properties of an optogenetic model for olfactory stimulation.The Journal of physiology · 2016Article
- The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Olfactory Receptors in Non-Chemosensory Organs: The Nervous System in Health and Disease.Frontiers in aging neuroscience · 2016Review
- Distinct functions of two olfactory marker protein genes derived from teleost-specific whole genome duplication.BMC evolutionary biology · 2015Article
- Olfactory marker protein expression is an indicator of olfactory receptor-associated events in non-olfactory tissues.PloS one · 2015Article
- The membrane proteome of sensory cilia to the depth of olfactory receptors.Molecular & cellular proteomics : MCP · 2014Article
- Heterotrimeric G protein subunit Gγ13 is critical to olfaction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundThe role of olfactory marker protein (OMP), a hallmark of mature olfactory sensory neurons (OSNs), has been poorly understood since its discovery. The electrophysiological and behavioral phenotypes of OMP knockout mice indicated that OMP influences olfactory signal transduction. However, the mechanism by which this occurs remained unknown. PRINCIPAL
findingsWe used intact olfactory epithelium obtained from WT and OMP(-/-) mice to monitor the Ca(2+) dynamics induced by the activation of cyclic nucleotide-gated channels, voltage-operated Ca(2+) channels, or Ca(2+) stores in single dendritic knobs of OSNs. Our data suggested that OMP could act to modulate the Ca(2+)-homeostasis in these neurons by influencing the activity of the plasma membrane Na(+)/Ca(2+)-exchanger (NCX). Immunohistochemistry verifies colocalization of NCX1 and OMP in the cilia and knobs of OSNs. To test the role of NCX activity, we compared the kinetics of Ca(2+) elevation by stimulating the reverse mode of NCX in both WT and OMP(-/-) mice. The resulting Ca(2+) responses indicate that OMP facilitates NCX activity and allows rapid Ca(2+) extrusion from OSN knobs. To address the mechanism by which OMP influences NCX activity in OSNs we studied protein-peptide interactions in real-time using surface plasmon resonance technology. We demonstrate the direct interaction of the XIP regulatory-peptide of NCX with calmodulin (CaM).
conclusionsSince CaM also binds to the Bex protein, an interacting protein partner of OMP, these observations strongly suggest that OMP can influence CaM efficacy and thus alters NCX activity by a series of protein-protein interactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.