ArticleArteriosclerosis, thrombosis, and vascular biology2009
The brachial artery remodels to maintain local shear stress despite the presence of cardiovascular risk factors.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Relative importance of step count, intensity, and duration on physical activity's impact on vascular structure and function in previously sedentary older adults.Journal of the American Heart Association · 2014Trial
- Associations of noninvasive measures of adiposity with aortic stiffness and microvascular function: The Jackson Heart Study.American journal of preventive cardiology · 2026Article
- Mediative role of body mass index in cardiorespiratory fitness-associated vascular remodeling in youth.Pediatric research · 2025Article
- Umbilical vein remodeling is associated with pregestational maternal overweight.Frontiers in endocrinology · 2024Article
- The effects of high-intensity interval training and moderate-intensity continuous training on visceral fat and carotid hemodynamics parameters in obese adults.Journal of exercise science and fitness · 2022Article
- Stair climbing activity and vascular function in patients with hypertension.Hypertension research : official journal of the Japanese Society of Hypertension · 2021Article
- Volume Elastic Modulus, Vascular Function, and Vascular Structure in Patients with Cardiovascular Risk Factors.Journal of atherosclerosis and thrombosis · 2021Article
- Gender differences in the risk factors associated with atherosclerosis by carotid intima-media thickness, plaque score, and pulse wave velocity.Heart and vessels · 2021Article
- Body Mass Index and Mortality From Aortic Aneurysm and Dissection.Journal of atherosclerosis and thrombosis · 2021Article
- Vascular diameter and intima-media thickness to diameter ratio values of the carotid artery in 642 healthy children.European journal of pediatrics · 2021Article
- Sleep Efficiency is Inversely Associated with Brachial Artery Diameter and Morning Blood Pressure in Midlife Adults, with a Potential Sex-Effect.Nature and science of sleep · 2021Article
- Clinical Associations of Vascular Stiffness, Microvascular Dysfunction, and Prevalent Cardiovascular Disease in a Black Cohort: The Jackson Heart Study.Journal of the American Heart Association · 2020Article
- Alterations in Vascular Function Associated With the Use of Combustible and Electronic Cigarettes.Journal of the American Heart Association · 2020Article
- Article
- Relations of Microvascular Function, Cardiovascular Disease Risk Factors, and Aortic Stiffness in Blacks: The Jackson Heart Study.Journal of the American Heart Association · 2018Observational
- Increased nitroglycerin-mediated vasodilation in migraineurs without aura in the interictal period.Journal of medical ultrasonics (2001) · 2018Article
- Interrelationships Among Flow-Mediated Vasodilation, Nitroglycerine-Induced Vasodilation, Baseline Brachial Artery Diameter, Hyperemic Shear Stress, and Cardiovascular Risk Factors.Journal of the American Heart Association · 2017Article
- Cross-Sectional Associations of Flow Reversal, Vascular Function, and Arterial Stiffness in the Framingham Heart Study.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- High shear stress induces atherosclerotic vulnerable plaque formation through angiogenesis.Regenerative biomaterials · 2016Review
- Obesity and carotid artery remodeling.Nutrition & diabetes · 2015Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectiveUnder physiological conditions, arteries remodel in response to changes in blood flow to maintain local shear stress. Risk factors and developing atherosclerosis may be associated with maladaptive remodeling that produces relatively large arteries with low levels of shear stress. Recent studies have shown that the brachial artery and other peripheral arteries are enlarged in patients with risk factors and cardiovascular disease, and we tested the hypothesis that this finding represents maladaptive remodeling. METHODS AND
resultsWe measured brachial artery diameter and flow by ultrasound and calculated shear stress in a diverse cohort of 1583 subjects (age 53+/-17 years, 62% male, and 51% with coronary artery disease and/or peripheral arterial disease). In a stepwise linear regression model, age (P<0.001), gender (P<0.001), body mass index (P<0.001), hypertension (P=0.005), and hypercholesterolemia (P=0.02) were associated with larger brachial diameter. Older age was associated with lower shear stress (P<0.01), consistent with maladaptive remodeling. However, body mass index, hypertension, hypercholesterolemia, and prevalent atherosclerosis were associated with proportionate changes in blood flow and no difference in shear stress compared to reference groups, suggesting adaptive remodeling.
conclusionsThese findings suggest that enlargement of the brachial artery in the setting of obesity, hypertension, hypercholesterolemia, and atherosclerosis reflects adaptive remodeling. The results provide further support for the concept that arterial remodeling is an important homeostatic response that is maintained despite the presence of risk factors and developing atherosclerosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.