Trial reportProceedings of the National Academy of Sciences of the United States of America2009
Evidence of gender differences in the ability to inhibit brain activation elicited by food stimulation.
Trial report in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 244 citations in OpenAlex.
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Sex/gender differences in neural correlates of food stimuli: a systematic review of functional neuroimaging studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2017Pooled it
- Food cue reactivity and craving predict eating and weight gain: a meta-analytic review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2016Pooled it
- Neural Responses to Auditory Food Stimuli Following Cognitive Behavioral Therapy for Binge-Eating Disorder.The International journal of eating disorders · 2024Trial
- Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.Scientific reports · 2021Trial
- Noninvasive neuromodulation of the prefrontal cortex in young women with obesity: a randomized clinical trial.International journal of obesity (2005) · 2020Trial
- Neuromodulation of the prefrontal cortex facilitates diet-induced weight loss in midlife women: a randomized, proof-of-concept clinical trial.International journal of obesity (2005) · 2020Trial
- Change in self-efficacy, eating behaviors and food cravings during two years of calorie restriction in humans without obesity.Appetite · 2019Trial
- Higher resting-state activity in reward-related brain circuits in obese versus normal-weight females independent of food intake.International journal of obesity (2005) · 2016Trial
- The effects of energy balance, obesity-proneness and sex on the neuronal response to sweet taste.Behavioural brain research · 2015Trial
- Neural circuits for cognitive appetite control in healthy and obese individuals: an fMRI study.PloS one · 2015Trial
- Dissociable Behavioral, Physiological and Neural Effects of Acute Glucose and Fructose Ingestion: A Pilot Study.PloS one · 2015Trial
- Ghrelin mimics fasting to enhance human hedonic, orbitofrontal cortex, and hippocampal responses to food.The American journal of clinical nutrition · 2014Trial
- Trial
- Sex-based fMRI differences in obese humans in response to high vs. low energy food cues.Behavioural brain research · 2013Trial
- Inducing negative affect increases the reward value of appetizing foods in dieters.Journal of cognitive neuroscience · 2012Trial
- Trial
- Acquired differences in brain responses among monozygotic twins discordant for restrained eating.Physiology & behavior · 2012Trial
- Reduced metabolism in brain "control networks" following cocaine-cues exposure in female cocaine abusers.PloS one · 2011Trial
- Prefrontal-striatal pathway underlies cognitive regulation of craving.Proceedings of the National Academy of Sciences of the United States of America · 2010Trial
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Although impaired inhibitory control is linked to a broad spectrum of health problems, including obesity, the brain mechanism(s) underlying voluntary control of hunger are not well understood. We assessed the brain circuits involved in voluntary inhibition of hunger during food stimulation in 23 fasted men and women using PET and 2-deoxy-2[(18)F]fluoro-D-glucose ((18)FDG). In men, but not in women, food stimulation with inhibition significantly decreased activation in amygdala, hippocampus, insula, orbitofrontal cortex, and striatum, which are regions involved in emotional regulation, conditioning, and motivation. The suppressed activation of the orbitofrontal cortex with inhibition in men was associated with decreases in self-reports of hunger, which corroborates the involvement of this region in processing the conscious awareness of the drive to eat. This finding suggests a mechanism by which cognitive inhibition decreases the desire for food and implicates lower ability to suppress hunger in women as a contributing factor to gender differences in obesity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.