ArticleProceedings of the National Academy of Sciences of the United States of America2009
Induction of TLR4-target genes entails calcium/calmodulin-dependent regulation of chromatin remodeling.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 46 citations in OpenAlex.
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- The Secretion of Inflammatory Cytokines Triggered by TLR2 Through Calcium-Dependent and Calcium-Independent Pathways in Keratinocytes.Mediators of inflammation · 2024Article
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- The Effects of Insulin-Like Growth Factor I and BTP-2 on Acute Lung Injury.International journal of molecular sciences · 2021Article
- Functional Diversity of Non-Histone Chromosomal Protein HmgB1.International journal of molecular sciences · 2020Review
- Regulation of the Mammalian SWI/SNF Family of Chromatin Remodeling Enzymes by Phosphorylation during Myogenesis.Biology · 2020Review
- Epigenetic regulation of the innate immune response to infection.Nature reviews. Immunology · 2019Review
- Flip-Flopping Retinal in Microbial Rhodopsins as a Template for a Farnesyl/Prenyl Flip-Flop Model in Eukaryote GPCRs.Frontiers in neuroscience · 2019Article
- Mode of Action of Farnesol, the "Noble Unknown" in Particular in CaFrontiers in neuroscience · 2019Article
- SMARCA4 regulates gene expression and higher-order chromatin structure in proliferating mammary epithelial cells.Genome research · 2016Article
- Transcriptional Activation of Inflammatory Genes: Mechanistic Insight into Selectivity and Diversity.Biomolecules · 2015Review
- Opposing calcium-dependent signalling pathways control skeletal muscle differentiation by regulating a chromatin remodelling enzyme.Nature communications · 2015Article
- Inducible mouse models illuminate parameters influencing epigenetic inheritance.Development (Cambridge, England) · 2013Article
- Low pH environmental stress inhibits LPS and LTA-stimulated proinflammatory cytokine production in rat alveolar macrophages.BioMed research international · 2013Article
- Lipopolysaccharide induces endoplasmic store Ca2+-dependent inflammatory responses in lung microvessels.PloS one · 2013Article
- The high mobility group box: the ultimate utility player of a cell.Trends in biochemical sciences · 2012Review
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
Abstract
Upon toll-like receptor 4 (TLR4) signaling in macrophages, the mammalian Swi/Snf-like BAF chromatin remodeling complex is recruited to many TLR4 target genes where it remodels their chromatin to promote transcription. Here, we show that, surprisingly, recruitment is not sufficient for chromatin remodeling; a second event, dependent on calcium/calmodulin (CaM), is additionally required. Calcium/CaM directly binds the HMG domain of the BAF57 subunit within the BAF complex. Calcium/CaM antagonists, including a CaM-binding peptide derived from BAF57, abolish BAF-dependent remodeling and gene expression without compromising BAF recruitment. BAF57 RNAi and BAF57 dominant negative mutants defective in CaM binding similarly impair the induction of BAF target genes. Our data implicate calcium/CaM in TLR4 signaling, and reveal a previously undescribed, recruitment-independent mode of regulation of the BAF complex that is probably achieved through a direct CaM-BAF interaction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.