ArticleProceedings of the National Academy of Sciences of the United States of America2009
Clathrin adaptor AP-1 complex excludes multiple postsynaptic receptors from axons in C. elegans.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Review
- Article
- Forgetting generates a novel state that is reactivatable.Science advances · 2022Article
- Structures of highly flexible intracellular domain of human α7 nicotinic acetylcholine receptor.Nature communications · 2022Article
- Spatial control of membrane traffic in neuronal dendrites.Molecular and cellular neurosciences · 2020Review
- Neuronal sub-compartmentalization: a strategy to optimize neuronal function.Biological reviews of the Cambridge Philosophical Society · 2019Review
- Neuronal functions of adaptor complexes involved in protein sorting.Current opinion in neurobiology · 2018Review
- Recent Findings on AMPA Receptor Recycling.Frontiers in cellular neuroscience · 2018Review
- UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes.PLoS genetics · 2017Article
- Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.Cell reports · 2016Article
- Rab5 and its effector FHF contribute to neuronal polarity through dynein-dependent retrieval of somatodendritic proteins from the axon.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A map of terminal regulators of neuronal identity in Caenorhabditis elegans.Wiley interdisciplinary reviews. Developmental biology · 2016Review
- Article
- Exclusion of integrins from CNS axons is regulated by Arf6 activation and the AIS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.Molecular biology of the cell · 2015Article
- Article
- Polarized sorting of the copper transporter ATP7B in neurons mediated by recognition of a dileucine signal by AP-1.Molecular biology of the cell · 2015Article
- Adaptor proteins involved in polarized sorting.The Journal of cell biology · 2014Review
- Cargo recognition in clathrin-mediated endocytosis.Cold Spring Harbor perspectives in biology · 2013Review
- Article
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Authors and funding
3 authors.
Funding
Abstract
Neurons are highly polarized cells with morphologically and molecularly distinct axonal and dendritic compartments. It is not well understood how postsynaptic receptors are selectively enriched in dendrites in vivo. We investigated the molecular mechanisms of dendritically polarized localization of a glutamate receptor, an acetylcholine receptor, and a ROR-type receptor tyrosine kinase in the interneuron RIA in C. elegans. We found that the clathrin adaptor AP-1 complex mu1 subunit UNC-101 functions cell autonomously to maintain the correct localization of these receptors in a dynamin-dependent manner. In unc-101 mutants, instead of being dendritically enriched, all 3 receptors are evenly distributed in the axonal and dendritic compartments. Surprisingly, UNC-101 predominantly localizes to the axonal compartment, suggesting a possible transcytosis model for the dendritic targeting of neurotransmitter receptors.
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