ArticleProceedings of the National Academy of Sciences of the United States of America2009
RNA-directed DNA methylation induces transcriptional activation in plants.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 93 citations in OpenAlex.
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- Unstable anthocyanin pigmentation in Streptocarpus sect. Saintpaulia (African violet) is due to transcriptional selectivity of a single MYB gene.The New phytologist · 2025Article
- RNAa: Mechanisms, therapeutic potential, and clinical progress.Molecular therapy. Nucleic acids · 2025Review
- A naturally occurring SNP modulates thermotolerance divergence among grapevines.Nature communications · 2025Article
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- Distinct ancient structural polymorphisms control heterodichogamy in walnuts and hickories.bioRxiv : the preprint server for biology · 2024Article
- Epigenetic regulation of plant immunity: from chromatin codes to plant disease resistance.aBIOTECH · 2023Review
- Oligo-Not Only for Silencing: Overlooked Potential for Multidirectional Action in Plants.International journal of molecular sciences · 2023Review
- Epigenetic Dynamics and Regulation of Plant Male Reproduction.International journal of molecular sciences · 2022Review
- NGenome biology · 2022Article
- The Underlying Nature of Epigenetic Variation: Origin, Establishment, and Regulatory Function of Plant Epialleles.International journal of molecular sciences · 2021Review
- Argonaute4 Modulates Resistance toPlant physiology · 2020Article
- Omics Potential in Herbicide-Resistant Weed Management.Plants (Basel, Switzerland) · 2019Review
- Genomic methylation in plant cell cultures: A barrier to the development of commercial long-term biofactories.Engineering in life sciences · 2019Review
- Meiocyte-Specific and AtSPO11-1-Dependent Small RNAs and Their Association with Meiotic Gene Expression and Recombination.The Plant cell · 2019Article
- A DNA methylation reader complex that enhances gene transcription.Science (New York, N.Y.) · 2018Article
- 5-Azacitidine Induces Cell Death in a Tissue Culture ofInternational journal of molecular sciences · 2018Article
- Article
- Oligodeoxynucleotides Can Transiently Up- and Downregulate CHS Gene Expression in Flax by Changing DNA Methylation in a Sequence-Specific Manner.Frontiers in plant science · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A class-C floral homeotic gene of Petunia, pMADS3, is specifically expressed in the stamen and carpels of developing flowers. We had previously reported the ect-pMADS3 phenomenon in which introduction of a part of the pMADS3 genomic sequence, including intron 2, induces ectopic expression of endogenous pMADS3. Unlike transcriptional or posttranscriptional gene silencing triggered by the introduction of homologous sequences, this observation is unique in that the gene expression is up-regulated. In this study, we demonstrated that the ect-pMADS3 phenomenon is due to transcriptional activation based on RNA-directed DNA methylation (RdDM) occurring in a particular CG in a putative cis-element in pMADS3 intron 2. The CG methylation was maintained over generations, along with pMADS3 ectopic expression, even in the absence of RNA triggers. These results demonstrate a previously undescribed transcriptional regulatory mechanism that could lead to the generation of a transcriptionally active epiallele, thereby contributing to plant evolution. Our results also reveal a putative negative cis-element for organ-specific transcriptional regulation of class-C floral homeotic genes, which could be difficult to identify by other approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.