ArticleThe American journal of pathology2009
Pneumonic plague pathogenesis and immunity in Brown Norway rats.
Article in The American journal of pathology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Antimicrobial Treatment and Prophylaxis of Plague: Recommendations for Naturally Acquired Infections and Bioterrorism Response.MMWR. Recommendations and reports : Morbidity and mortality weekly report. Recommendations and reports · 2021Guideline
- Microscopic and Molecular Identification ofAnimals : an open access journal from MDPI · 2026Article
- Development and evaluation of a triplex real-time PCR assay for enhanced plague diagnostics in Madagascar.PLoS neglected tropical diseases · 2025Article
- Navigating ESKAPE Pathogens: Considerations and Caveats for Animal Infection Models Development.ACS infectious diseases · 2024Review
- Recombinant YopE and LcrV vaccine candidates protect mice against plague and yersiniosis.Heliyon · 2024Article
- Protection Induced by Oral Vaccination with a RecombinantInfection and immunity · 2022Article
- One year immunogenicity and safety of subunit plague vaccine in Chinese healthy adults: An extended open-label study.Human vaccines & immunotherapeutics · 2018Article
- Considerations for Infectious Disease Research Studies Using Animals.Comparative medicine · 2017Review
- Spatially distinct neutrophil responses within the inflammatory lesions of pneumonic plague.mBio · 2015Article
- Remote monitoring of the progression of primary pneumonic plague in Brown Norway rats in high-capacity, high-containment housing.Pathogens and disease · 2014Article
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- Protecting against plague: towards a next-generation vaccine.Clinical and experimental immunology · 2013Review
- Characterization of systemic and pneumonic murine models of plague infection using a conditionally virulent strain.Comparative immunology, microbiology and infectious diseases · 2013Article
- A novel post-exposure medical countermeasure L-97-1 improves survival and acute lung injury following intratracheal infection with Yersinia pestis.Innate immunity · 2012Article
- Polymorphisms in the lcrV gene of Yersinia enterocolitica and their effect on plague protective immunity.Infection and immunity · 2012Article
- Host stress and immune responses during aerosol challenge of Brown Norway rats with Yersinia pestis.Frontiers in cellular and infection microbiology · 2012Article
- The role of immune correlates and surrogate markers in the development of vaccines and immunotherapies for plague.Advances in preventive medicine · 2012Article
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- Article
- Plague: Infections of Companion Animals and Opportunities for Intervention.Animals : an open access journal from MDPI · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
The Brown Norway rat was recently described as a bubonic plague model that closely mimics human disease. We therefore evaluated the Brown Norway rat as an alternative small animal model for pneumonic plague and characterized both the efficacy and potency of vaccine candidates. When infected by intranasal instillation, these rats rapidly developed fatal pneumonic plague within 2 to 4 days of infection. Plague disease was characterized by severe alveolar edema and vascular hemorrhage in the lung in addition to fulminant necrotizing pneumonia caused by massive bacterial replication and inflammation. Twenty-four hours before death, animals developed systemic disease with an apparent delayed inflammatory response. We evaluated the ability of the protective antigen, LcrV, and a mutant derivative, V10, to protect these rats from pneumonic plague. Both were highly effective vaccines because complete protection was observed at challenge doses of 7500 LD(50). Antibody analyses suggested stronger potency of V10 immune sera compared with LcrV in the passive transfer of immunity to bubonic plague, with multiple neutralizing epitopes in LcrV. Taken together, these data demonstrate the effectiveness of inhibiting type III secretion in the prevention of pneumonic plague in rats and reveal critical contributions from both the cellular and humoral immune systems. Thus, the Brown Norway rat is an appealing alternative small animal model for the study of pneumonic plague pathogenesis and immunity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.