ArticleMolecular endocrinology (Baltimore, Md.)2009
Insulin regulates TRB3 and other stress-responsive gene expression through induction of C/EBPbeta.
Article in Molecular endocrinology (Baltimore, Md.), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 32 citations in OpenAlex.
- Evaluation of sestrin 2 and tribbles homolog 3 levels in obese and nonobese women with polycystic ovary syndrome.Turkish journal of medical sciences · 2023Article
- Article
- Increased expression of tribbles homolog 3 predicts poor prognosis and correlates with tumor immunity in clear cell renal cell carcinoma: a bioinformatics study.Bioengineered · 2022Article
- TRIB3‒GSK-3Acta pharmaceutica Sinica. B · 2021Article
- Decreased 11β-Hydroxysteroid Dehydrogenase Type 2 Expression in the Kidney May Contribute to Nicotine/Smoking-Induced Blood Pressure Elevation in Mice.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Obesity-induced TRB3 negatively regulates Brown adipose tissue function in mice.Biochemical and biophysical research communications · 2021Article
- TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation.Nature communications · 2020Article
- PML-RARα interaction with TRIB3 impedes PPARγ/RXR function and triggers dyslipidemia in acute promyelocytic leukemia.Theranostics · 2020Article
- Governing roles for Trib3 pseudokinase during stress erythropoiesis.Experimental hematology · 2017Article
- Article
- TRB3 links insulin/IGF to tumour promotion by interacting with p62 and impeding autophagic/proteasomal degradations.Nature communications · 2015Article
- Overexpression of TRB3 in muscle alters muscle fiber type and improves exercise capacity in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2014Article
- Drosophila tribbles antagonizes insulin signaling-mediated growth and metabolism via interactions with Akt kinase.PloS one · 2014Article
- Interaction of constitutive photomorphogenesis 1 protein with protein-tyrosine phosphatase 1B suppresses protein-tyrosine phosphatase 1B activity and enhances insulin signaling.The Journal of biological chemistry · 2013Article
- Tribbles 3 mediates endoplasmic reticulum stress-induced insulin resistance in skeletal muscle.Nature communications · 2013Article
- Role of TRIB3 in regulation of insulin sensitivity and nutrient metabolism during short-term fasting and nutrient excess.American journal of physiology. Endocrinology and metabolism · 2012Article
- The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.Endocrine reviews · 2012Review
- The contribution of endoplasmic reticulum stress to liver diseases.Hepatology (Baltimore, Md.) · 2011Article
- Article
- The anti-inflammatory and immunosuppressive effects of glucocorticoids, recent developments and mechanistic insights.Molecular and cellular endocrinology · 2011Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pseudokinase TRB3 is an inducible gene whose expression is regulated by stress response and insulin and associated with insulin resistance and metabolic syndrome. In this report, we have investigated the mechanism under which insulin regulates TRB3 gene expression and demonstrated that insulin induces TRB3 expression via C/EBPbeta. We found that in Fao hepatoma and 3T3-L1 adipocytes, C/EBPbeta expression induced by insulin preceded that of TRB3 and that mutation of the C/EBPbeta binding site in TRB3 promoter abolished the responsiveness of the TRB3 gene to insulin. We further showed that ectopic expression of C/EBPbeta augmented, whereas knockdown of C/EBPbeta reduced, TRB3 expression induced by insulin. In addition, we presented data to show that insulin, through a similar mechanism under which insulin induces TRB3 expression, promotes the expression of genes such as ANAS, ATF3, BIP, and CHOP, which are typical stress-responsive genes. We also examined the impact of C/EBPbeta expression on Akt activation and found that inaction of C/EBPbeta not only augmented Akt activation but also obliterated the suppression of Akt activation due to prolonged insulin stimulation. We suggest, through induction of C/EBPbeta in hepatic cells and adipocytes, that insulin induces the expression of stress-responsive genes, which may represent a novel insulin action.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.