ReviewTrends in molecular medicine2009
What are microarrays teaching us about sleep?
Review in Trends in molecular medicine, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 71 citations in OpenAlex.
- Widespread changes in white matter microstructure after a day of waking and sleep deprivation.PloS one · 2015Trial
- Effects of insufficient sleep on circadian rhythmicity and expression amplitude of the human blood transcriptome.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Molecular correlates of sleep deprivation in the mouse brain identified by meta-analysis of microarray data.Neurobiology of sleep and circadian rhythms · 2026Article
- Astrocytes in Post-traumatic Stress Disorder.Neuroscience bulletin · 2022Review
- Article
- Role of sleep deprivation in immune-related disease risk and outcomes.Communications biology · 2021Review
- Unique transcriptional signatures of sleep loss across independently evolved cavefish populations.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2020Article
- Age attenuates the transcriptional changes that occur with sleep in the medial prefrontal cortex.Aging cell · 2019Article
- The role of modifiable health-related behaviors in the association between PTSD and respiratory illness.Behaviour research and therapy · 2019Article
- Circadian rhythm and sleep-wake systems share the dynamic extracellular synaptic milieu.Neurobiology of sleep and circadian rhythms · 2018Review
- Exploring gene expression biomarker candidates for neurobehavioral impairment from total sleep deprivation.BMC genomics · 2018Article
- Sleep-Wake Cycling and Energy Conservation: Role of Hypocretin and the Lateral Hypothalamus in Dynamic State-Dependent Resource Optimization.Frontiers in neurology · 2018Review
- Plasticity and Susceptibility of Brain Morphometry Alterations to Insufficient Sleep.Frontiers in psychiatry · 2018Article
- Molecular Mechanisms of Sleep Homeostasis in Flies and Mammals.Cold Spring Harbor perspectives in biology · 2017Review
- Article
- The adenosine-mediated, neuronal-glial, homeostatic sleep response.Current opinion in neurobiology · 2017Review
- Circadian Rhythms and Sleep inGenetics · 2017Review
- State-dependent metabolic partitioning and energy conservation: A theoretical framework for understanding the function of sleep.PloS one · 2017Article
- The role of sleep in recovery following ischemic stroke: A review of human and animal data.Neurobiology of sleep and circadian rhythms · 2017Review
- Unraveling the Evolutionary Determinants of Sleep.Current biology : CB · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Many fundamental questions about sleep remain unanswered. The presence of sleep across phyla suggests that it must serve a basic cellular and/or molecular function. Microarray studies, performed in several model systems, have identified classes of genes that are sleep-state regulated. This has led to the following concepts: first, a function of sleep is to maintain synaptic homeostasis; second, sleep is a stage of macromolecule biosynthesis; third, extending wakefulness leads to downregulation of several important metabolic pathways; and, fourth, extending wakefulness leads to endoplasmic reticulum stress. In human studies, microarrays are being applied to the identification of biomarkers for sleepiness and for the common debilitating condition of obstructive sleep apnea.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.