ArticleJournal of the neurological sciences2009
Deep gray matter T2 hypointensity correlates with disability in a murine model of MS.
Article in Journal of the neurological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Article
- Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis.Journal of visualized experiments : JoVE · 2016Article
- Thalamus pathology in multiple sclerosis: from biology to clinical application.Cellular and molecular life sciences : CMLS · 2015Review
- Understanding disease processes in multiple sclerosis through magnetic resonance imaging studies in animal models.NeuroImage. Clinical · 2014Review
- Unilateral hemispherectomy at adulthood asymmetrically affects motor performance of male Swiss mice.Experimental brain research · 2012Article
- Article
- Pathogenic implications of iron accumulation in multiple sclerosis.Journal of neurochemistry · 2012Review
- Contrasting roles for CD4 vs. CD8 T-cells in a murine model of virally induced "T1 black hole" formation.PloS one · 2012Article
- The relevance of animal models in multiple sclerosis research.Pathophysiology : the official journal of the International Society for Pathophysiology · 2011Article
- Brain atrophy correlates with functional outcome in a murine model of multiple sclerosis.NeuroImage · 2011Article
- MRI in rodent models of brain disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2011Review
- Towards a unifying, systems biology understanding of large-scale cellular death and destruction caused by poorly liganded iron: Parkinson's, Huntington's, Alzheimer's, prions, bactericides, chemical toxicology and others as examples.Archives of toxicology · 2010Review
- Viral models of multiple sclerosis: neurodegeneration and demyelination in mice infected with Theiler's virus.Progress in neurobiologyArticle
- Correlation of Brain Atrophy, Disability, and Spinal Cord Atrophy in a Murine Model of Multiple Sclerosis.Journal of neuroimaging : official journal of the American Society of NeuroimagingArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Advanced MRI studies demonstrated several diffuse non-lesional features in multiple sclerosis, including changes detectable in gray matter areas. Standard T2 weighted MRI scans of deep gray matter structures, including the thalamus, caudate, putamen, dentate nuclei often demonstrate hypointensity. T2 hypointensity has been shown to correlate with cognitive, neuropsychiatric and motor dysfunction. The exact pathogenesis of this MRI phenomenon remains unknown. In this manuscript, we demonstrate the first known MS animal model of deep gray matter T2 hypointensity. In TMEV infected SJL/J mice, gradual development of thalamic T2 hypointensity was noted over the disease course. Quantitative analysis of the hypointensity demonstrated a strong correlation between the degree of T2 hypointensity and rotarod detectable disability. We propose that this model will allow mechanistic studies investigating the pathogenesis and significance of deep gray matter T2 hypointensity in MS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.